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Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals
The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8–14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), F...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973231/ https://www.ncbi.nlm.nih.gov/pubmed/27487746 http://dx.doi.org/10.1038/srep31106 |
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author | Botezelli, José D. Coope, Andressa Ghezzi, Ana C. Cambri, Lucieli T. Moura, Leandro P. Scariot, Pedro P. M. Gaspar, Rodrigo Stellzer Mekary, Rania A. Ropelle, Eduardo Rochete Pauli, José Rodrigo |
author_facet | Botezelli, José D. Coope, Andressa Ghezzi, Ana C. Cambri, Lucieli T. Moura, Leandro P. Scariot, Pedro P. M. Gaspar, Rodrigo Stellzer Mekary, Rania A. Ropelle, Eduardo Rochete Pauli, José Rodrigo |
author_sort | Botezelli, José D. |
collection | PubMed |
description | The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8–14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P < 0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases. |
format | Online Article Text |
id | pubmed-4973231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49732312016-08-11 Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals Botezelli, José D. Coope, Andressa Ghezzi, Ana C. Cambri, Lucieli T. Moura, Leandro P. Scariot, Pedro P. M. Gaspar, Rodrigo Stellzer Mekary, Rania A. Ropelle, Eduardo Rochete Pauli, José Rodrigo Sci Rep Article The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8–14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P < 0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases. Nature Publishing Group 2016-08-04 /pmc/articles/PMC4973231/ /pubmed/27487746 http://dx.doi.org/10.1038/srep31106 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Botezelli, José D. Coope, Andressa Ghezzi, Ana C. Cambri, Lucieli T. Moura, Leandro P. Scariot, Pedro P. M. Gaspar, Rodrigo Stellzer Mekary, Rania A. Ropelle, Eduardo Rochete Pauli, José Rodrigo Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals |
title | Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals |
title_full | Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals |
title_fullStr | Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals |
title_full_unstemmed | Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals |
title_short | Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals |
title_sort | strength training prevents hyperinsulinemia, insulin resistance, and inflammation independent of weight loss in fructose-fed animals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973231/ https://www.ncbi.nlm.nih.gov/pubmed/27487746 http://dx.doi.org/10.1038/srep31106 |
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