Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus

TOR signaling pathway regulator-like (TIPRL) is a regulatory protein which inhibits the catalytic subunits of Type 2A phosphatases. Several cellular contexts have been proposed for TIPRL, such as regulation of mTOR signaling, inhibition of apoptosis and biogenesis and recycling of PP2A, however, the...

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Detalles Bibliográficos
Autores principales: Scorsato, Valéria, Lima, Tatiani B., Righetto, Germanna L., Zanchin, Nilson I. T., Brandão-Neto, José, Sandy, James, Pereira, Humberto D’Muniz, Ferrari, Állan J. R., Gozzo, Fabio C., Smetana, Juliana H. C., Aparicio, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973239/
https://www.ncbi.nlm.nih.gov/pubmed/27489114
http://dx.doi.org/10.1038/srep30813

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