Cargando…

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

A single amyloidogenic protein is implicated in multiple neurological diseases and capable of generating a number of aggregate “strains” with distinct structures. Among the amyloidogenic proteins, α-synuclein generates multiple patterns of proteinopathies in a group of diseases, such as Parkinson di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Changyoun, Lv, Guohua, Lee, Jun Sung, Jung, Byung Chul, Masuda-Suzukake, Masami, Hong, Chul-Suk, Valera, Elvira, Lee, He-Jin, Paik, Seung R., Hasegawa, Masato, Masliah, Eliezer, Eliezer, David, Lee, Seung-Jae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973277/ https://www.ncbi.nlm.nih.gov/pubmed/27488222 http://dx.doi.org/10.1038/srep30891

Ejemplares similares

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2
por: Kim, Changyoun, et al.
Publicado: (2016)

Pathological alpha-synuclein propagates through neural networks
por: Masuda-Suzukake, Masami, et al.
Publicado: (2014)

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
por: Kim, Changyoun, et al.
Publicado: (2018)

Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification
por: Jung, Byung Chul, et al.
Publicado: (2017)

A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
por: Spencer, Brian, et al.
Publicado: (2015)

Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
por: Kim, Changyoun, et al.
Publicado: (2021)

Prion-like spreading of pathological α-synuclein in brain
por: Masuda-Suzukake, Masami, et al.
Publicado: (2013)

Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
por: Awa, Shiori, et al.
Publicado: (2022)

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
por: Bae, Eun-Jin, et al.
Publicado: (2018)

Role of Synucleins in Alzheimer’s Disease
por: Crews, Leslie, et al.
Publicado: (2009)

Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets
por: Kwon, Somin, et al.
Publicado: (2020)

Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
por: Kwon, Somin, et al.
Publicado: (2019)

Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models
por: Iba, Michiyo, et al.
Publicado: (2020)

Progression of phosphorylated α‐synuclein in Macaca fuscata
por: Kawakami, Ito, et al.
Publicado: (2021)

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
por: Iba, Michiyo, et al.
Publicado: (2020)

Propagation of pathological α-synuclein in marmoset brain
por: Shimozawa, Aki, et al.
Publicado: (2017)

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases
por: Mund, Thomas, et al.
Publicado: (2018)

Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection
por: Lee, He-Jin, et al.
Publicado: (2010)

Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy
por: Valera, Elvira, et al.
Publicado: (2017)

α‐synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease
por: Spencer, Brian, et al.
Publicado: (2016)

Radiating Amyloid Fibril Formation on the Surface of Lipid Membranes through Unit-Assembly of Oligomeric Species of α-Synuclein
por: Lee, Jung-Ho, et al.
Publicado: (2012)

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
por: Spencer, Brian, et al.
Publicado: (2017)

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease
por: Foulds, Penelope G., et al.
Publicado: (2013)

Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS
por: Szabo, Marcell P., et al.
Publicado: (2022)

MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy
por: Valera, Elvira, et al.
Publicado: (2017)

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson’s disease
por: Valera, Elvira, et al.
Publicado: (2015)

Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson's Disease
por: Wei, Jianshe, et al.
Publicado: (2021)

Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein
por: Sekigawa, Akio, et al.
Publicado: (2012)

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease
por: Kim, Changyoun, et al.
Publicado: (2015)

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein
por: Frieg, Benedikt, et al.
Publicado: (2022)

Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
por: Regensburger, Martin, et al.
Publicado: (2020)

Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD
por: Iba, Michiyo, et al.
Publicado: (2022)

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
por: Mandler, Markus, et al.
Publicado: (2015)

Granular Assembly of α-Synuclein Leading to the Accelerated Amyloid Fibril Formation with Shear Stress
por: Bhak, Ghibom, et al.
Publicado: (2009)

Specific Detection of Physiological S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay
por: Arlinghaus, Ryan, et al.
Publicado: (2023)

Molecular and functional interactions of alpha-synuclein with Rab3a
por: Lv, Guohua, et al.
Publicado: (2022)

Dextran sulphate-induced tau assemblies cause endogenous tau aggregation and propagation in wild-type mice
por: Masuda-Suzukake, Masami, et al.
Publicado: (2020)

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
por: Strohäker, Timo, et al.
Publicado: (2019)

Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease
por: Kaul, Tiffany, et al.
Publicado: (2011)

The Temporal Expression Pattern of Alpha-Synuclein Modulates Olfactory Neurogenesis in Transgenic Mice
por: Schreglmann, Sebastian R., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fegp16f6410k763r6udups8dog