Cargando…

Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established human colorectal cancer (CRC) cell lines and CRC patient tissues. Moreover, Sur8 expression is inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Young-Mi, Kaduwal, Saluja, Lee, Kug Hwa, Park, Jong-Chan, Jeong, Woo-Jeong, Choi, Kang-Yell
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973316/ https://www.ncbi.nlm.nih.gov/pubmed/27469030 http://dx.doi.org/10.1038/emm.2016.58

Ejemplares similares

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling
por: Kaduwal, Saluja, et al.
Publicado: (2015)

Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells
por: Lee, Kug Hwa, et al.
Publicado: (2017)

K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis
por: Koo, Kyoung-Hwa, et al.
Publicado: (2015)

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer
por: Cho, Yong-Hee, et al.
Publicado: (2016)

WDR76 mediates obesity and hepatic steatosis via HRas destabilization
por: Park, Jong-Chan, et al.
Publicado: (2019)

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
por: Ro, Eun Ji, et al.
Publicado: (2019)

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
por: Cho, Yong-Hee, et al.
Publicado: (2020)

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway
por: Jeong, Woo-Jeong, et al.
Publicado: (2018)

tgCRISPRi: efficient gene knock-down using truncated gRNAs and catalytically active Cas9
por: Auradkar, Ankush, et al.
Publicado: (2023)

Percolation transition of cooperative mutational effects in colorectal tumorigenesis
por: Shin, Dongkwan, et al.
Publicado: (2017)

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling
por: Shin, Wookjin, et al.
Publicado: (2018)

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells
por: Kang, Dong Woo, et al.
Publicado: (2015)

Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells
por: Hwang, Won Chan, et al.
Publicado: (2014)

NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer
por: Chung, Hsin-Hua, et al.
Publicado: (2020)

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells
por: Cho, Yong-Hee, et al.
Publicado: (2020)

KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2
por: Yan, Qingqing, et al.
Publicado: (2015)

Geijigajakyak decoction inhibits the motility and tumorigenesis of colorectal cancer cells
por: Lee, Soong-in, et al.
Publicado: (2016)

Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF
por: Ko, Aram, et al.
Publicado: (2012)

Roles of Tristetraprolin in Tumorigenesis
por: Park, Jeong-Min, et al.
Publicado: (2018)

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
por: Jeong, Woo-Jeong, et al.
Publicado: (2019)

Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis
por: Bian, Benjamin, et al.
Publicado: (2015)

Expressional Difference of RHEB, HDAC1, and WEE1 Proteins in the Stromal Tumors of the Breast and Their Significance in Tumorigenesis
por: Eom, Minseob, et al.
Publicado: (2012)

RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis
por: Xia, Yan, et al.
Publicado: (2017)

Verification of the role of exosomal microRNA in colorectal tumorigenesis using human colorectal cancer cell lines
por: Noh, Gyoung Tae, et al.
Publicado: (2020)

Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review
por: Song, Yanan, et al.
Publicado: (2020)

Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair
por: Kim, Eunhwan, et al.
Publicado: (2023)

APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer
por: Cha, Pu-Hyeon, et al.
Publicado: (2020)

Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer
por: Cha, Pu-Hyeon, et al.
Publicado: (2016)

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab
por: Lee, Sang-Kyu, et al.
Publicado: (2018)

Blockade of CXXC5-dishevelled interaction inhibits adipogenic differentiation, obesity, and insulin resistance in mice
por: Seo, Seol Hwa, et al.
Publicado: (2022)

Adducin in tumorigenesis and metastasis
por: Luo, Cong, et al.
Publicado: (2017)

High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma
por: Kim, Young-Sik, et al.
Publicado: (2019)

Prognosis and Sensitivity of Adjuvant Chemotherapy in Mucinous Colorectal Adenocarcinoma without Distant Metastasis
por: Bong, Jun-Woo, et al.
Publicado: (2022)

Plakoglobin: Role in Tumorigenesis and Metastasis
por: Aktary, Zackie, et al.
Publicado: (2012)

Inflammation-Induced Tumorigenesis and Metastasis
por: Hibino, Sana, et al.
Publicado: (2021)

Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development
por: Park, Ju Young, et al.
Publicado: (2014)

Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer
por: Shin, Dong Hoon, et al.
Publicado: (2020)

The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer
por: Wang, Zhongyuan, et al.
Publicado: (2021)

Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
por: Hu, Xiaoding, et al.
Publicado: (2021)

Pancreatic Metastasis and Obstructive Jaundice in Small Cell Lung Carcinoma
por: Jeong, In Beom, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_mhsl6nfdv4892rdboc4oas2e0t