PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL

Proteins involved in DNA double-strand break (DSB) repair localize within the promyelocytic leukemia nuclear bodies (PML-NBs), whose disruption is at the root of the acute promyelocytic leukemia (APL) pathogenesis. All-trans-retinoic acid (RA) treatment induces PML-RARα degradation, restores PML-NB...

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Detalles Bibliográficos
Autores principales: di Masi, A, Cilli, D, Berardinelli, F, Talarico, A, Pallavicini, I, Pennisi, R, Leone, S, Antoccia, A, Noguera, N I, Lo-Coco, F, Ascenzi, P, Minucci, S, Nervi, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973339/
https://www.ncbi.nlm.nih.gov/pubmed/27468685
http://dx.doi.org/10.1038/cddis.2016.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973339/
https://www.ncbi.nlm.nih.gov/pubmed/27468685
http://dx.doi.org/10.1038/cddis.2016.115

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