PGA(1)-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes

The cyclopentenone prostaglandin A(1) (PGA(1)) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA(1) triggers apoptosis by a process that entails the specific activation of H- and N-Ras isoforms, leading...

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Detalles Bibliográficos
Autores principales: Anta, B, Pérez-Rodríguez, A, Castro, J, García- Domínguez, C A, Ibiza, S, Martínez, N, Durá, L M, Hernández, S, Gragera, T, Peña-Jiménez, D, Yunta, M, Zarich, N, Crespo, P, Serrador, J M, Santos, E, Muñoz, A, Oliva, J L, Rojas-Cabañeros, J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973357/
https://www.ncbi.nlm.nih.gov/pubmed/27468687
http://dx.doi.org/10.1038/cddis.2016.219

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