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Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6

Cereblon (CRBN) is a substrate receptor protein for the CRL4A E3 ubiquitin ligase complex. In this study, we report on a new regulatory role of CRBN in TLR4 signaling. CRBN overexpression leads to suppression of NF-κB activation and production of pro-inflammatory cytokines including IL-6 and IL-1β i...

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Detalles Bibliográficos
Autores principales:	Min, Yoon, Wi, Sae Mi, Kang, Jung-Ah, Yang, Taewoo, Park, Chul-Seung, Park, Sung-Gyoo, Chung, Sungkwon, Shim, Jae-Hyuck, Chun, Eunyoung, Lee, Ki-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973362/ https://www.ncbi.nlm.nih.gov/pubmed/27468689 http://dx.doi.org/10.1038/cddis.2016.226

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