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Nuclear-targeting TAT-PEG-Asp(8)-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer
AIM: Drug efflux-associated multidrug resistance (MDR) is a main obstacle to effective cancer chemotherapy. Large molecule drugs are not the substrates of P-glycoprotein, and can circumvent drug efflux and be retained inside cells. In this article we report a polymer-drug conjugate nanoparticulate s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973383/ https://www.ncbi.nlm.nih.gov/pubmed/27292613 http://dx.doi.org/10.1038/aps.2016.48 |