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Nuclear-targeting TAT-PEG-Asp(8)-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer

AIM: Drug efflux-associated multidrug resistance (MDR) is a main obstacle to effective cancer chemotherapy. Large molecule drugs are not the substrates of P-glycoprotein, and can circumvent drug efflux and be retained inside cells. In this article we report a polymer-drug conjugate nanoparticulate s...

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Detalles Bibliográficos
Autores principales:	Pan, Zhen-zhen, Wang, Hui-yuan, Zhang, Meng, Lin, Ting-ting, Zhang, Wen-yuan, Zhao, Peng-fei, Tang, Yi-si, Xiong, Yong, Zeng, Yuan-er, Huang, Yong-zhuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973383/ https://www.ncbi.nlm.nih.gov/pubmed/27292613 http://dx.doi.org/10.1038/aps.2016.48

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