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The conformational signature of arrestin3 predicts its trafficking and signaling functions

Arrestins are cytosolic proteins that regulate G protein-coupled receptor (GPCR) desensitization, internalization, trafficking, and signaling(1,2). Arrestin recruitment uncouples GPCRs from heterotrimeric G proteins, and targets them for internalization via clathrin-coated pits(3,4). Arrestins also...

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Detalles Bibliográficos
Autores principales:	Lee, Mi-Hye, Appleton, Kathryn M., Strungs, Erik G., Kwon, Joshua Y., Morinelli, Thomas A., Peterson, Yuri K., Laporte, Stephane A., Luttrell, Louis M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973468/ https://www.ncbi.nlm.nih.gov/pubmed/27007854 http://dx.doi.org/10.1038/nature17154

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