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How to make striatal projection neurons

Medium spiny neurons (MSNs) are the main projection neurons of the striatum and are preferentially lost in Huntington's disease (HD). With no current cure for this neurodegenerative disorder, the specificity of neuronal loss in the striatum makes cell transplantation therapy an attractive avenu...

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Detalles Bibliográficos
Autores principales: Fjodorova, Marija, Noakes, Zoe, Li, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973609/
https://www.ncbi.nlm.nih.gov/pubmed/27606330
http://dx.doi.org/10.1080/23262133.2015.1100227
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author Fjodorova, Marija
Noakes, Zoe
Li, Meng
author_facet Fjodorova, Marija
Noakes, Zoe
Li, Meng
author_sort Fjodorova, Marija
collection PubMed
description Medium spiny neurons (MSNs) are the main projection neurons of the striatum and are preferentially lost in Huntington's disease (HD). With no current cure for this neurodegenerative disorder, the specificity of neuronal loss in the striatum makes cell transplantation therapy an attractive avenue for its treatment. Also, given that MSNs are particularly vulnerable in HD, it is necessary to understand why these neurons degenerate in order to develop new therapeutic options. Both approaches require access to human MSN progenitors and their mature neuronal derivatives. Human embryonic stem cells and HD patient induced pluripotent stem cells (together referred to as hPSCs) may serve as an unlimited source of such tissue if they can be directed toward authentic striatal neuronal lineage. Understanding the MSN differentiation pathway in the brain is therefore of paramount importance for the generation of accurate protocols to obtain striatal cells in vitro. The focus of this mini review will be on striatal development and current methods to generate MSNs from hPSCs.
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spelling pubmed-49736092016-12-15 How to make striatal projection neurons Fjodorova, Marija Noakes, Zoe Li, Meng Neurogenesis (Austin) Mini-Review Medium spiny neurons (MSNs) are the main projection neurons of the striatum and are preferentially lost in Huntington's disease (HD). With no current cure for this neurodegenerative disorder, the specificity of neuronal loss in the striatum makes cell transplantation therapy an attractive avenue for its treatment. Also, given that MSNs are particularly vulnerable in HD, it is necessary to understand why these neurons degenerate in order to develop new therapeutic options. Both approaches require access to human MSN progenitors and their mature neuronal derivatives. Human embryonic stem cells and HD patient induced pluripotent stem cells (together referred to as hPSCs) may serve as an unlimited source of such tissue if they can be directed toward authentic striatal neuronal lineage. Understanding the MSN differentiation pathway in the brain is therefore of paramount importance for the generation of accurate protocols to obtain striatal cells in vitro. The focus of this mini review will be on striatal development and current methods to generate MSNs from hPSCs. Taylor & Francis 2015-12-15 /pmc/articles/PMC4973609/ /pubmed/27606330 http://dx.doi.org/10.1080/23262133.2015.1100227 Text en © 2015 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Mini-Review
Fjodorova, Marija
Noakes, Zoe
Li, Meng
How to make striatal projection neurons
title How to make striatal projection neurons
title_full How to make striatal projection neurons
title_fullStr How to make striatal projection neurons
title_full_unstemmed How to make striatal projection neurons
title_short How to make striatal projection neurons
title_sort how to make striatal projection neurons
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973609/
https://www.ncbi.nlm.nih.gov/pubmed/27606330
http://dx.doi.org/10.1080/23262133.2015.1100227
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