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Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
INTRODUCTION: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973765/ https://www.ncbi.nlm.nih.gov/pubmed/27512342 http://dx.doi.org/10.4137/CMO.S38333 |
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author | Jammal, Millena Prata Martins-Filho, Agrimaldo Silveira, Thales Parenti Murta, Eddie Fernando Candido Nomelini, Rosekeila Simões |
author_facet | Jammal, Millena Prata Martins-Filho, Agrimaldo Silveira, Thales Parenti Murta, Eddie Fernando Candido Nomelini, Rosekeila Simões |
author_sort | Jammal, Millena Prata |
collection | PubMed |
description | INTRODUCTION: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. METHOD: The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms. A panel of cytokines was evaluated by immunohistochemistry (Th1: IL-2 and IL-8; Th2: IL-5, IL-6, and IL-10; and TNFR1). Chi-square test with Yates’ correction was used, which was considered significant if less than 0.05. RESULTS: TNFR1, IL-5, and IL-10 had more frequent immunostaining 2/3 in benign neoplasms compared with malignant tumors. Malignant tumors had more frequent immunostaining 2/3 for IL-2 in relation to benign tumors. The immunostaining 0/1 of IL 8 was more frequent in the stroma of benign neoplasms compared with malignant neoplasms. Evaluation of the ovarian cancer stroma showed that histological grade 3 was significantly correlated with staining 2/3 for IL-2 (P = 0.004). Women whose disease-free survival was less than 2.5 years had TNFR1 stromal staining 2/3 (P = 0.03) more frequently. CONCLUSION: IL-2 and TNFR1 stromal immunostaining are related prognostic factors in ovarian cancer and can be the target of new therapeutic strategies. |
format | Online Article Text |
id | pubmed-4973765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-49737652016-08-10 Cytokines and Prognostic Factors in Epithelial Ovarian Cancer Jammal, Millena Prata Martins-Filho, Agrimaldo Silveira, Thales Parenti Murta, Eddie Fernando Candido Nomelini, Rosekeila Simões Clin Med Insights Oncol Original Research INTRODUCTION: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. METHOD: The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms. A panel of cytokines was evaluated by immunohistochemistry (Th1: IL-2 and IL-8; Th2: IL-5, IL-6, and IL-10; and TNFR1). Chi-square test with Yates’ correction was used, which was considered significant if less than 0.05. RESULTS: TNFR1, IL-5, and IL-10 had more frequent immunostaining 2/3 in benign neoplasms compared with malignant tumors. Malignant tumors had more frequent immunostaining 2/3 for IL-2 in relation to benign tumors. The immunostaining 0/1 of IL 8 was more frequent in the stroma of benign neoplasms compared with malignant neoplasms. Evaluation of the ovarian cancer stroma showed that histological grade 3 was significantly correlated with staining 2/3 for IL-2 (P = 0.004). Women whose disease-free survival was less than 2.5 years had TNFR1 stromal staining 2/3 (P = 0.03) more frequently. CONCLUSION: IL-2 and TNFR1 stromal immunostaining are related prognostic factors in ovarian cancer and can be the target of new therapeutic strategies. Libertas Academica 2016-08-02 /pmc/articles/PMC4973765/ /pubmed/27512342 http://dx.doi.org/10.4137/CMO.S38333 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Original Research Jammal, Millena Prata Martins-Filho, Agrimaldo Silveira, Thales Parenti Murta, Eddie Fernando Candido Nomelini, Rosekeila Simões Cytokines and Prognostic Factors in Epithelial Ovarian Cancer |
title | Cytokines and Prognostic Factors in Epithelial Ovarian Cancer |
title_full | Cytokines and Prognostic Factors in Epithelial Ovarian Cancer |
title_fullStr | Cytokines and Prognostic Factors in Epithelial Ovarian Cancer |
title_full_unstemmed | Cytokines and Prognostic Factors in Epithelial Ovarian Cancer |
title_short | Cytokines and Prognostic Factors in Epithelial Ovarian Cancer |
title_sort | cytokines and prognostic factors in epithelial ovarian cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973765/ https://www.ncbi.nlm.nih.gov/pubmed/27512342 http://dx.doi.org/10.4137/CMO.S38333 |
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