Cargando…

Cytokines and Prognostic Factors in Epithelial Ovarian Cancer

INTRODUCTION: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and...

Descripción completa

Detalles Bibliográficos
Autores principales: Jammal, Millena Prata, Martins-Filho, Agrimaldo, Silveira, Thales Parenti, Murta, Eddie Fernando Candido, Nomelini, Rosekeila Simões
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973765/
https://www.ncbi.nlm.nih.gov/pubmed/27512342
http://dx.doi.org/10.4137/CMO.S38333
_version_ 1782446449949147136
author Jammal, Millena Prata
Martins-Filho, Agrimaldo
Silveira, Thales Parenti
Murta, Eddie Fernando Candido
Nomelini, Rosekeila Simões
author_facet Jammal, Millena Prata
Martins-Filho, Agrimaldo
Silveira, Thales Parenti
Murta, Eddie Fernando Candido
Nomelini, Rosekeila Simões
author_sort Jammal, Millena Prata
collection PubMed
description INTRODUCTION: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. METHOD: The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms. A panel of cytokines was evaluated by immunohistochemistry (Th1: IL-2 and IL-8; Th2: IL-5, IL-6, and IL-10; and TNFR1). Chi-square test with Yates’ correction was used, which was considered significant if less than 0.05. RESULTS: TNFR1, IL-5, and IL-10 had more frequent immunostaining 2/3 in benign neoplasms compared with malignant tumors. Malignant tumors had more frequent immunostaining 2/3 for IL-2 in relation to benign tumors. The immunostaining 0/1 of IL 8 was more frequent in the stroma of benign neoplasms compared with malignant neoplasms. Evaluation of the ovarian cancer stroma showed that histological grade 3 was significantly correlated with staining 2/3 for IL-2 (P = 0.004). Women whose disease-free survival was less than 2.5 years had TNFR1 stromal staining 2/3 (P = 0.03) more frequently. CONCLUSION: IL-2 and TNFR1 stromal immunostaining are related prognostic factors in ovarian cancer and can be the target of new therapeutic strategies.
format Online
Article
Text
id pubmed-4973765
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Libertas Academica
record_format MEDLINE/PubMed
spelling pubmed-49737652016-08-10 Cytokines and Prognostic Factors in Epithelial Ovarian Cancer Jammal, Millena Prata Martins-Filho, Agrimaldo Silveira, Thales Parenti Murta, Eddie Fernando Candido Nomelini, Rosekeila Simões Clin Med Insights Oncol Original Research INTRODUCTION: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. METHOD: The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms. A panel of cytokines was evaluated by immunohistochemistry (Th1: IL-2 and IL-8; Th2: IL-5, IL-6, and IL-10; and TNFR1). Chi-square test with Yates’ correction was used, which was considered significant if less than 0.05. RESULTS: TNFR1, IL-5, and IL-10 had more frequent immunostaining 2/3 in benign neoplasms compared with malignant tumors. Malignant tumors had more frequent immunostaining 2/3 for IL-2 in relation to benign tumors. The immunostaining 0/1 of IL 8 was more frequent in the stroma of benign neoplasms compared with malignant neoplasms. Evaluation of the ovarian cancer stroma showed that histological grade 3 was significantly correlated with staining 2/3 for IL-2 (P = 0.004). Women whose disease-free survival was less than 2.5 years had TNFR1 stromal staining 2/3 (P = 0.03) more frequently. CONCLUSION: IL-2 and TNFR1 stromal immunostaining are related prognostic factors in ovarian cancer and can be the target of new therapeutic strategies. Libertas Academica 2016-08-02 /pmc/articles/PMC4973765/ /pubmed/27512342 http://dx.doi.org/10.4137/CMO.S38333 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Jammal, Millena Prata
Martins-Filho, Agrimaldo
Silveira, Thales Parenti
Murta, Eddie Fernando Candido
Nomelini, Rosekeila Simões
Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
title Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
title_full Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
title_fullStr Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
title_full_unstemmed Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
title_short Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
title_sort cytokines and prognostic factors in epithelial ovarian cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973765/
https://www.ncbi.nlm.nih.gov/pubmed/27512342
http://dx.doi.org/10.4137/CMO.S38333
work_keys_str_mv AT jammalmillenaprata cytokinesandprognosticfactorsinepithelialovariancancer
AT martinsfilhoagrimaldo cytokinesandprognosticfactorsinepithelialovariancancer
AT silveirathalesparenti cytokinesandprognosticfactorsinepithelialovariancancer
AT murtaeddiefernandocandido cytokinesandprognosticfactorsinepithelialovariancancer
AT nomelinirosekeilasimoes cytokinesandprognosticfactorsinepithelialovariancancer