Polyion complex (PIC) particles: Preparation and biomedical applications

Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and chemical sensors to detect disease markers. A comprehensive...

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Detalles Bibliográficos
Autores principales: Insua, Ignacio, Wilkinson, Andrew, Fernandez-Trillo, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973809/
https://www.ncbi.nlm.nih.gov/pubmed/27524831
http://dx.doi.org/10.1016/j.eurpolymj.2016.06.003
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author Insua, Ignacio
Wilkinson, Andrew
Fernandez-Trillo, Francisco
author_facet Insua, Ignacio
Wilkinson, Andrew
Fernandez-Trillo, Francisco
author_sort Insua, Ignacio
collection PubMed
description Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and chemical sensors to detect disease markers. A comprehensive discussion of the factors affecting PIC particle self-assembly and their response to physical and chemical stimuli in solution is described herein. Finally, a collection of key examples of polyionic nanoparticles for biomedical applications is discussed to illustrate their behaviour and demonstrate the potential of PIC nanoparticles in medicine.
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spelling pubmed-49738092016-08-11 Polyion complex (PIC) particles: Preparation and biomedical applications Insua, Ignacio Wilkinson, Andrew Fernandez-Trillo, Francisco Eur Polym J Article Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and chemical sensors to detect disease markers. A comprehensive discussion of the factors affecting PIC particle self-assembly and their response to physical and chemical stimuli in solution is described herein. Finally, a collection of key examples of polyionic nanoparticles for biomedical applications is discussed to illustrate their behaviour and demonstrate the potential of PIC nanoparticles in medicine. Pergamon Press 2016-08 /pmc/articles/PMC4973809/ /pubmed/27524831 http://dx.doi.org/10.1016/j.eurpolymj.2016.06.003 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Insua, Ignacio
Wilkinson, Andrew
Fernandez-Trillo, Francisco
Polyion complex (PIC) particles: Preparation and biomedical applications
title Polyion complex (PIC) particles: Preparation and biomedical applications
title_full Polyion complex (PIC) particles: Preparation and biomedical applications
title_fullStr Polyion complex (PIC) particles: Preparation and biomedical applications
title_full_unstemmed Polyion complex (PIC) particles: Preparation and biomedical applications
title_short Polyion complex (PIC) particles: Preparation and biomedical applications
title_sort polyion complex (pic) particles: preparation and biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973809/
https://www.ncbi.nlm.nih.gov/pubmed/27524831
http://dx.doi.org/10.1016/j.eurpolymj.2016.06.003
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