FANCD2 limits replication stress and genome instability in cells lacking BRCA2

The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication fork progression and genomic insta...

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Detalles Bibliográficos
Autores principales: Michl, Johanna, Zimmer, Jutta, Buffa, Francesca M., McDermott, Ultan, Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973888/
https://www.ncbi.nlm.nih.gov/pubmed/27322732
http://dx.doi.org/10.1038/nsmb.3252
Descripción
Sumario:The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication fork progression and genomic instability. Our results identify a novel role for FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, which impacts on cell survival and treatment responses.

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