FANCD2 limits replication stress and genome instability in cells lacking BRCA2

The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication fork progression and genomic insta...

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Autores principales: Michl, Johanna, Zimmer, Jutta, Buffa, Francesca M., McDermott, Ultan, Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973888/
https://www.ncbi.nlm.nih.gov/pubmed/27322732
http://dx.doi.org/10.1038/nsmb.3252
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author Michl, Johanna
Zimmer, Jutta
Buffa, Francesca M.
McDermott, Ultan
Tarsounas, Madalena
author_facet Michl, Johanna
Zimmer, Jutta
Buffa, Francesca M.
McDermott, Ultan
Tarsounas, Madalena
author_sort Michl, Johanna
collection PubMed
description The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication fork progression and genomic instability. Our results identify a novel role for FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, which impacts on cell survival and treatment responses.
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spelling pubmed-49738882016-12-20 FANCD2 limits replication stress and genome instability in cells lacking BRCA2 Michl, Johanna Zimmer, Jutta Buffa, Francesca M. McDermott, Ultan Tarsounas, Madalena Nat Struct Mol Biol Article The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication fork progression and genomic instability. Our results identify a novel role for FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, which impacts on cell survival and treatment responses. 2016-06-20 2016-08 /pmc/articles/PMC4973888/ /pubmed/27322732 http://dx.doi.org/10.1038/nsmb.3252 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Michl, Johanna
Zimmer, Jutta
Buffa, Francesca M.
McDermott, Ultan
Tarsounas, Madalena
FANCD2 limits replication stress and genome instability in cells lacking BRCA2
title FANCD2 limits replication stress and genome instability in cells lacking BRCA2
title_full FANCD2 limits replication stress and genome instability in cells lacking BRCA2
title_fullStr FANCD2 limits replication stress and genome instability in cells lacking BRCA2
title_full_unstemmed FANCD2 limits replication stress and genome instability in cells lacking BRCA2
title_short FANCD2 limits replication stress and genome instability in cells lacking BRCA2
title_sort fancd2 limits replication stress and genome instability in cells lacking brca2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973888/
https://www.ncbi.nlm.nih.gov/pubmed/27322732
http://dx.doi.org/10.1038/nsmb.3252
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