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Identification of Novel Smoothened Ligands Using Structure-Based Docking

The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and medulloblastoma, and Smoothened inhibitors are now av...

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Detalles Bibliográficos
Autores principales:	Lacroix, Celine, Fish, Inbar, Torosyan, Hayarpi, Parathaman, Pranavan, Irwin, John J., Shoichet, Brian K., Angers, Stephane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973902/ https://www.ncbi.nlm.nih.gov/pubmed/27490099 http://dx.doi.org/10.1371/journal.pone.0160365

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