Cargando…

HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells

BACKGROUND: During short-term hypoxia, Hypoxia Inducible Factors (particular their subunits HIF-1α and HIF-2α) regulate the expression of many genes including the potent angiogenesis stimulator VEGF. However, in some pathological conditions chronic hypoxia occurs and is accompanied by reduced angiog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nauta, Tessa D., Duyndam, Monique C. A., Weijers, Ester M., van Hinsbergh, Victor M. W., Koolwijk, Pieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973926/ https://www.ncbi.nlm.nih.gov/pubmed/27490118 http://dx.doi.org/10.1371/journal.pone.0160700

Ejemplares similares

Correction: HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells
por: Nauta, Tessa D., et al.
Publicado: (2016)

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro
por: Nauta, Tessa D., et al.
Publicado: (2016)

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity
por: Tasev, Dimitar, et al.
Publicado: (2015)

Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential
por: Tasev, Dimitar, et al.
Publicado: (2018)

Hypoxic Signaling During Tissue Repair and Regenerative Medicine
por: Nauta, Tessa D., et al.
Publicado: (2014)

Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices
por: Knezevic, Lea, et al.
Publicado: (2017)

Fibrin and Collagen Differentially but Synergistically Regulate Sprout Angiogenesis of Human Dermal Microvascular Endothelial Cells in 3-Dimensional Matrix
por: Feng, Xiaodong, et al.
Publicado: (2013)

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
por: Juni, Rio P., et al.
Publicado: (2019)

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants
por: Boas, Sonja E. M., et al.
Publicado: (2018)

Single and combined effects of αvβ3- and α5β1-integrins on capillary tube formation in a human fibrinous matrix
por: Laurens, Nancy, et al.
Publicado: (2009)

Skin substitutes are more potent than dermal or epidermal substitutes in stimulating endothelial cell sprouting
por: Monsuur, Hanneke N., et al.
Publicado: (2019)

Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering
por: Monsuur, Hanneke N., et al.
Publicado: (2016)

The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances
por: Attaye, Ilias, et al.
Publicado: (2017)

Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic sclerosis
por: Mao, Jing, et al.
Publicado: (2022)

CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs)
por: Tasev, Dimitar, et al.
Publicado: (2016)

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia
por: Cavadas, Miguel A. S., et al.
Publicado: (2015)

Qiliqiangxin attenuates hypoxia‐induced injury in primary rat cardiac microvascular endothelial cells via promoting HIF‐1α‐dependent glycolysis
por: Wang, Yanyan, et al.
Publicado: (2018)

Mesenchymal stem cells support human vascular endothelial cells to form vascular sprouts in human platelet lysate-based matrices
por: Summer, Sabrina, et al.
Publicado: (2022)

Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis
por: Shao, Zhuo, et al.
Publicado: (2013)

Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia
por: Cohen, Emily B., et al.
Publicado: (2020)

The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
por: Jaśkiewicz, Maciej, et al.
Publicado: (2022)

Microscale spatial heterogeneity of protein structural transitions in fibrin matrices
por: Fleissner, Frederik, et al.
Publicado: (2016)

Correction: Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis
por: Shao, Zhuo, et al.
Publicado: (2013)

Effect of Age and Diabetes on the Response of Mesenchymal Progenitor Cells to Fibrin Matrices
por: Stolzing, A., et al.
Publicado: (2011)

Impact of g force and timing on the characteristics of platelet-rich fibrin matrices
por: Castro, Ana B., et al.
Publicado: (2021)

Opposing Effects of the Angiopoietins on the Thrombin-Induced Permeability of Human Pulmonary Microvascular Endothelial Cells
por: van der Heijden, Melanie, et al.
Publicado: (2011)

Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
por: Liu, Jifeng, et al.
Publicado: (2021)

Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis
por: Salomon, Carlos, et al.
Publicado: (2013)

Tongxinluo Reverses the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells
por: Liu, Kun, et al.
Publicado: (2016)

Hyperoxia Reprogrammes Microvascular Endothelial Cell Response to Hypoxia in an Organ-Specific Manner
por: Reiterer, Moritz, et al.
Publicado: (2022)

RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells
por: Liu, Yanhua, et al.
Publicado: (2017)

Hypoxia Augments Outgrowth Endothelial Cell (OEC) Sprouting and Directed Migration in Response to Sphingosine-1-Phosphate (S1P)
por: Williams, Priscilla A., et al.
Publicado: (2015)

Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro
por: Baumann, Julia, et al.
Publicado: (2021)

Hypoxia-inducible factor (HIF)-3a2 serves as an endothelial cell fate executor during chronic hypoxia
por: Jaskiewicz, Maciej, et al.
Publicado: (2022)

Fibrillin-1 regulates endothelial sprouting during angiogenesis
por: Alonso, Florian, et al.
Publicado: (2023)

The Effect of Velvet Antler Proteins on Cardiac Microvascular Endothelial Cells Challenged with Ischemia-Hypoxia
por: Xiao, Xiang, et al.
Publicado: (2017)

Effect of Hypoxia Preconditioned Secretomes on Lymphangiogenic and Angiogenic Sprouting: An in Vitro Analysis
por: Moog, Philipp, et al.
Publicado: (2020)

Diabetes affects endothelial cell function and alters fibrin clot formation in a microvascular flow model: A pilot study
por: Jenny, Lorenz, et al.
Publicado: (2020)

Therapeutic arteriogenesis by factor-decorated fibrin matrices promotes wound healing in diabetic mice
por: D’Amico, Rosalinda, et al.
Publicado: (2022)

Mechanism of hif-1α mediated hypoxia-induced permeability changes in bladder endothelial cells
por: Liu, C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_upkf58neril1nic0oomku1dbia