Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo

Heparan sulphate (HS), a ubiquitously expressed glycosaminoglycan (GAG), regulates multiple cellular functions by mediating interactions between numerous growth factors and their cell surface cognate receptors. However, the structural specificity of HS in these interactions remains largely undefined...

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Detalles Bibliográficos
Autores principales: Avizienyte, Egle, Cole, Claire L., Rushton, Graham, Miller, Gavin J., Bugatti, Antonella, Presta, Marco, Gardiner, John M., Jayson, Gordon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973927/
https://www.ncbi.nlm.nih.gov/pubmed/27490176
http://dx.doi.org/10.1371/journal.pone.0159739

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