Functional Translational Readthrough: A Systems Biology Perspective

Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon....

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Detalles Bibliográficos
Autores principales: Schueren, Fabian, Thoms, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973966/
https://www.ncbi.nlm.nih.gov/pubmed/27490485
http://dx.doi.org/10.1371/journal.pgen.1006196
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author Schueren, Fabian
Thoms, Sven
author_facet Schueren, Fabian
Thoms, Sven
author_sort Schueren, Fabian
collection PubMed
description Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.
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spelling pubmed-49739662016-08-18 Functional Translational Readthrough: A Systems Biology Perspective Schueren, Fabian Thoms, Sven PLoS Genet Review Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries. Public Library of Science 2016-08-04 /pmc/articles/PMC4973966/ /pubmed/27490485 http://dx.doi.org/10.1371/journal.pgen.1006196 Text en © 2016 Schueren, Thoms http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Schueren, Fabian
Thoms, Sven
Functional Translational Readthrough: A Systems Biology Perspective
title Functional Translational Readthrough: A Systems Biology Perspective
title_full Functional Translational Readthrough: A Systems Biology Perspective
title_fullStr Functional Translational Readthrough: A Systems Biology Perspective
title_full_unstemmed Functional Translational Readthrough: A Systems Biology Perspective
title_short Functional Translational Readthrough: A Systems Biology Perspective
title_sort functional translational readthrough: a systems biology perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973966/
https://www.ncbi.nlm.nih.gov/pubmed/27490485
http://dx.doi.org/10.1371/journal.pgen.1006196
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