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Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria

The ecological context in which mosquitoes and malaria parasites interact has received little attention, compared to the genetic and molecular aspects of malaria transmission. Plant nectar and fruits are important for the nutritional ecology of malaria vectors, but how the natural diversity of plant...

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Autores principales: Hien, Domonbabele F. d. S., Dabiré, Kounbobr R., Roche, Benjamin, Diabaté, Abdoulaye, Yerbanga, Rakiswende S., Cohuet, Anna, Yameogo, Bienvenue K., Gouagna, Louis-Clément, Hopkins, Richard J., Ouedraogo, Georges A., Simard, Frédéric, Ouedraogo, Jean-Bosco, Ignell, Rickard, Lefevre, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973987/
https://www.ncbi.nlm.nih.gov/pubmed/27490374
http://dx.doi.org/10.1371/journal.ppat.1005773
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author Hien, Domonbabele F. d. S.
Dabiré, Kounbobr R.
Roche, Benjamin
Diabaté, Abdoulaye
Yerbanga, Rakiswende S.
Cohuet, Anna
Yameogo, Bienvenue K.
Gouagna, Louis-Clément
Hopkins, Richard J.
Ouedraogo, Georges A.
Simard, Frédéric
Ouedraogo, Jean-Bosco
Ignell, Rickard
Lefevre, Thierry
author_facet Hien, Domonbabele F. d. S.
Dabiré, Kounbobr R.
Roche, Benjamin
Diabaté, Abdoulaye
Yerbanga, Rakiswende S.
Cohuet, Anna
Yameogo, Bienvenue K.
Gouagna, Louis-Clément
Hopkins, Richard J.
Ouedraogo, Georges A.
Simard, Frédéric
Ouedraogo, Jean-Bosco
Ignell, Rickard
Lefevre, Thierry
author_sort Hien, Domonbabele F. d. S.
collection PubMed
description The ecological context in which mosquitoes and malaria parasites interact has received little attention, compared to the genetic and molecular aspects of malaria transmission. Plant nectar and fruits are important for the nutritional ecology of malaria vectors, but how the natural diversity of plant-derived sugar sources affects mosquito competence for malaria parasites is unclear. To test this, we infected Anopheles coluzzi, an important African malaria vector, with sympatric field isolates of Plasmodium falciparum, using direct membrane feeding assays. Through a series of experiments, we then examined the effects of sugar meals from Thevetia neriifolia and Barleria lupilina cuttings that included flowers, and fruit from Lannea microcarpa and Mangifera indica on parasite and mosquito traits that are key for determining the intensity of malaria transmission. We found that the source of plant sugar meal differentially affected infection prevalence and intensity, the development duration of the parasites, as well as the survival and fecundity of the vector. These effects are likely the result of complex interactions between toxic secondary metabolites and the nutritional quality of the plant sugar source, as well as of host resource availability and parasite growth. Using an epidemiological model, we show that plant sugar source can be a significant driver of malaria transmission dynamics, with some plant species exhibiting either transmission-reducing or -enhancing activities.
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spelling pubmed-49739872016-08-18 Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria Hien, Domonbabele F. d. S. Dabiré, Kounbobr R. Roche, Benjamin Diabaté, Abdoulaye Yerbanga, Rakiswende S. Cohuet, Anna Yameogo, Bienvenue K. Gouagna, Louis-Clément Hopkins, Richard J. Ouedraogo, Georges A. Simard, Frédéric Ouedraogo, Jean-Bosco Ignell, Rickard Lefevre, Thierry PLoS Pathog Research Article The ecological context in which mosquitoes and malaria parasites interact has received little attention, compared to the genetic and molecular aspects of malaria transmission. Plant nectar and fruits are important for the nutritional ecology of malaria vectors, but how the natural diversity of plant-derived sugar sources affects mosquito competence for malaria parasites is unclear. To test this, we infected Anopheles coluzzi, an important African malaria vector, with sympatric field isolates of Plasmodium falciparum, using direct membrane feeding assays. Through a series of experiments, we then examined the effects of sugar meals from Thevetia neriifolia and Barleria lupilina cuttings that included flowers, and fruit from Lannea microcarpa and Mangifera indica on parasite and mosquito traits that are key for determining the intensity of malaria transmission. We found that the source of plant sugar meal differentially affected infection prevalence and intensity, the development duration of the parasites, as well as the survival and fecundity of the vector. These effects are likely the result of complex interactions between toxic secondary metabolites and the nutritional quality of the plant sugar source, as well as of host resource availability and parasite growth. Using an epidemiological model, we show that plant sugar source can be a significant driver of malaria transmission dynamics, with some plant species exhibiting either transmission-reducing or -enhancing activities. Public Library of Science 2016-08-04 /pmc/articles/PMC4973987/ /pubmed/27490374 http://dx.doi.org/10.1371/journal.ppat.1005773 Text en © 2016 Hien et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hien, Domonbabele F. d. S.
Dabiré, Kounbobr R.
Roche, Benjamin
Diabaté, Abdoulaye
Yerbanga, Rakiswende S.
Cohuet, Anna
Yameogo, Bienvenue K.
Gouagna, Louis-Clément
Hopkins, Richard J.
Ouedraogo, Georges A.
Simard, Frédéric
Ouedraogo, Jean-Bosco
Ignell, Rickard
Lefevre, Thierry
Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
title Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
title_full Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
title_fullStr Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
title_full_unstemmed Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
title_short Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria
title_sort plant-mediated effects on mosquito capacity to transmit human malaria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973987/
https://www.ncbi.nlm.nih.gov/pubmed/27490374
http://dx.doi.org/10.1371/journal.ppat.1005773
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