What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases

The lateral habenula (LHb) is believed to convey an aversive or “anti-reward” signal, but its contribution to reward-related action selection is unknown. We found that LHb inactivation abolished choice biases, making rats indifferent when choosing between rewards associated with different subjective...

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Detalles Bibliográficos
Autores principales: Stopper, Colin M., Floresco, Stan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974073/
https://www.ncbi.nlm.nih.gov/pubmed/24270185
http://dx.doi.org/10.1038/nn.3587
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author Stopper, Colin M.
Floresco, Stan B.
author_facet Stopper, Colin M.
Floresco, Stan B.
author_sort Stopper, Colin M.
collection PubMed
description The lateral habenula (LHb) is believed to convey an aversive or “anti-reward” signal, but its contribution to reward-related action selection is unknown. We found that LHb inactivation abolished choice biases, making rats indifferent when choosing between rewards associated with different subjective costs and magnitudes, but not larger/smaller rewards of equal cost. Thus, instead of serving as an aversion center, the evolutionarily-conserved LHb acts as preference center integral for expressing subjective decision biases.
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spelling pubmed-49740732016-08-04 What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases Stopper, Colin M. Floresco, Stan B. Nat Neurosci Article The lateral habenula (LHb) is believed to convey an aversive or “anti-reward” signal, but its contribution to reward-related action selection is unknown. We found that LHb inactivation abolished choice biases, making rats indifferent when choosing between rewards associated with different subjective costs and magnitudes, but not larger/smaller rewards of equal cost. Thus, instead of serving as an aversion center, the evolutionarily-conserved LHb acts as preference center integral for expressing subjective decision biases. 2013-11-24 2014-01 /pmc/articles/PMC4974073/ /pubmed/24270185 http://dx.doi.org/10.1038/nn.3587 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Stopper, Colin M.
Floresco, Stan B.
What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases
title What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases
title_full What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases
title_fullStr What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases
title_full_unstemmed What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases
title_short What’s better for me? Fundamental role for lateral habenula in promoting subjective decision biases
title_sort what’s better for me? fundamental role for lateral habenula in promoting subjective decision biases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974073/
https://www.ncbi.nlm.nih.gov/pubmed/24270185
http://dx.doi.org/10.1038/nn.3587
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