The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity

Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS), and the increased presence of TDP-43 in the cytoplasm is a prominent histopathological feature of degenerating neurons in various neurodegenerative diseases. However, the molecular mechanisms by which...

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Detalles Bibliográficos
Autores principales: Wang, Wenzhang, Wang, Luwen, Lu, Junjie, Siedlak, Sandra L., Fujioka, Hisashi, Liang, Jingjing, Jiang, Sirui, Ma, Xiaopin, Jiang, Zhen, da Rocha, Edroaldo Lummertz, Sheng, Max, Choi, Heewon, Lerou, Paul H., Li, Hu, Wang, Xinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974139/
https://www.ncbi.nlm.nih.gov/pubmed/27348499
http://dx.doi.org/10.1038/nm.4130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974139/
https://www.ncbi.nlm.nih.gov/pubmed/27348499
http://dx.doi.org/10.1038/nm.4130

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