Cargando…

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zervou, Sevasti, Yin, Xiaoke, Nabeebaccus, Adam A., O’Brien, Brett A., Cross, Rebecca L., McAndrew, Debra J., Atkinson, R. Andrew, Eykyn, Thomas R., Mayr, Manuel, Neubauer, Stefan, Lygate, Craig A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Vienna 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974297/ https://www.ncbi.nlm.nih.gov/pubmed/27143170 http://dx.doi.org/10.1007/s00726-016-2236-x

Ejemplares similares

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
por: Lygate, Craig A., et al.
Publicado: (2022)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
por: McAndrew, Debra J., et al.
Publicado: (2022)

Myocardial Creatine Levels Do Not Influence Response to Acute Oxidative Stress in Isolated Perfused Heart
por: Aksentijević, Dunja, et al.
Publicado: (2014)

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion
por: Whittington, Hannah J, et al.
Publicado: (2018)

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure
por: Cao, Fang, et al.
Publicado: (2020)

Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice
por: Aksentijević, Dunja, et al.
Publicado: (2020)

Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution (31)P-CMRS in the mouse
por: Maguire, Mahon L., et al.
Publicado: (2023)

Augmentation of Creatine in the Heart
por: Zervou, Sevasti, et al.
Publicado: (2016)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis
por: Zervou, Sevasti, et al.
Publicado: (2013)

The creatine kinase system as a therapeutic target for myocardial ischaemia–reperfusion injury
por: Cao, Fang, et al.
Publicado: (2018)

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine
por: Faller, Kiterie M E, et al.
Publicado: (2018)

Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia
por: Whittington, Hannah J., et al.
Publicado: (2016)

Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart
por: Zervou, Sevasti, et al.
Publicado: (2021)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
por: Lygate, Craig A., et al.
Publicado: (2012)

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro
por: Zervou, Sevasti, et al.
Publicado: (2017)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction
por: Lygate, Craig A., et al.
Publicado: (2012)

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity
por: Aksentijević, Dunja, et al.
Publicado: (2014)

Creatine uptake in mouse hearts with genetically altered creatine levels
por: Hove, Michiel ten, et al.
Publicado: (2008)

(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism
por: Faller, Kiterie M. E., et al.
Publicado: (2012)

Changes in creatine transporter function during cardiac maturation in the rat
por: Fischer, Alexandra, et al.
Publicado: (2010)

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart
por: Faller, Kiterie M. E., et al.
Publicado: (2013)

The Pitfalls of in vivo Cardiac Physiology in Genetically Modified Mice – Lessons Learnt the Hard Way in the Creatine Kinase System
por: Lygate, Craig A.
Publicado: (2021)

Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale
por: Faller, Kiterie M. E., et al.
Publicado: (2015)

Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T
por: Clarke, William T., et al.
Publicado: (2019)

Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?
por: Aksentijevic, Dunja, et al.
Publicado: (2018)

Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome
por: Yin, Xiaoke, et al.
Publicado: (2013)

Creatine Supplementation in Children and Adolescents
por: Jagim, Andrew R., et al.
Publicado: (2021)

Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation
por: Nabeebaccus, Adam A., et al.
Publicado: (2017)

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism
por: Stockebrand, Malte, et al.
Publicado: (2018)

Is creatine a CNS neurotransmitter?
por: Mallik, Bhagaban, et al.
Publicado: (2023)

A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate
por: Jagim, Andrew R, et al.
Publicado: (2012)

In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism
por: Carducci, Claudia, et al.
Publicado: (2012)

Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus
por: Ruparelia, Neil, et al.
Publicado: (2013)

The creatine kinase system and pleiotropic effects of creatine
por: Wallimann, Theo, et al.
Publicado: (2011)

Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling
por: Young, Alistair A, et al.
Publicado: (2011)

Creatine in Health and Disease
por: Kreider, Richard B., et al.
Publicado: (2021)

The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health?
por: Clarke, Holly, et al.
Publicado: (2020)

The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males
por: Andre, Tom, et al.
Publicado: (2015)

Accurate infarct-size measurements from accelerated, compressed sensing reconstructed cine-MRI images in mouse hearts
por: Wech, Tobias, et al.
Publicado: (2012)

Creatine salts provide neuroprotection even after partial impairment of the creatine transporter
por: Adriano, E., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6a9o3gl1usb6tkf2qiru11217k