The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria

Copper-transporting ATPase ATP7A is essential for mammalian copper homeostasis. Loss of ATP7A activity is associated with fatal Menkes disease and various other pathologies. In cells, ATP7A inactivation disrupts copper transport from the cytosol into the secretory pathway. Using fibroblasts from Men...

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Detalles Bibliográficos
Autores principales: Bhattacharjee, Ashima, Yang, Haojun, Duffy, Megan, Robinson, Emily, Conrad-Antoville, Arianrhod, Lu, Ya-Wen, Capps, Tony, Braiterman, Lelita, Wolfgang, Michael, Murphy, Michael P., Yi, Ling, Kaler, Stephen G., Lutsenko, Svetlana, Ralle, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974379/
https://www.ncbi.nlm.nih.gov/pubmed/27226607
http://dx.doi.org/10.1074/jbc.M116.727248

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