Who Regulates Whom? An Overview of RNA Granules and Viral Infections

After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized...

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Autores principales: Poblete-Durán, Natalia, Prades-Pérez, Yara, Vera-Otarola, Jorge, Soto-Rifo, Ricardo, Valiente-Echeverría, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974515/
https://www.ncbi.nlm.nih.gov/pubmed/27367717
http://dx.doi.org/10.3390/v8070180
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author Poblete-Durán, Natalia
Prades-Pérez, Yara
Vera-Otarola, Jorge
Soto-Rifo, Ricardo
Valiente-Echeverría, Fernando
author_facet Poblete-Durán, Natalia
Prades-Pérez, Yara
Vera-Otarola, Jorge
Soto-Rifo, Ricardo
Valiente-Echeverría, Fernando
author_sort Poblete-Durán, Natalia
collection PubMed
description After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs).
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spelling pubmed-49745152016-08-08 Who Regulates Whom? An Overview of RNA Granules and Viral Infections Poblete-Durán, Natalia Prades-Pérez, Yara Vera-Otarola, Jorge Soto-Rifo, Ricardo Valiente-Echeverría, Fernando Viruses Review After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs). MDPI 2016-06-28 /pmc/articles/PMC4974515/ /pubmed/27367717 http://dx.doi.org/10.3390/v8070180 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Poblete-Durán, Natalia
Prades-Pérez, Yara
Vera-Otarola, Jorge
Soto-Rifo, Ricardo
Valiente-Echeverría, Fernando
Who Regulates Whom? An Overview of RNA Granules and Viral Infections
title Who Regulates Whom? An Overview of RNA Granules and Viral Infections
title_full Who Regulates Whom? An Overview of RNA Granules and Viral Infections
title_fullStr Who Regulates Whom? An Overview of RNA Granules and Viral Infections
title_full_unstemmed Who Regulates Whom? An Overview of RNA Granules and Viral Infections
title_short Who Regulates Whom? An Overview of RNA Granules and Viral Infections
title_sort who regulates whom? an overview of rna granules and viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974515/
https://www.ncbi.nlm.nih.gov/pubmed/27367717
http://dx.doi.org/10.3390/v8070180
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