EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

Diffuse invasion of the surrounding brain parenchyma is a major obstacle in the treatment of gliomas with various therapeutics, including anti-angiogenic agents. Here we identify the epi-/genetic and microenvironmental downregulation of ephrinB2 as a crucial step that promotes tumour invasion by abr...

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Detalles Bibliográficos
Autores principales: Depner, C., zum Buttel, H., Böğürcü, N., Cuesta, A. M., Aburto, M. R., Seidel, S., Finkelmeier, F., Foss, F., Hofmann, J., Kaulich, K., Barbus, S., Segarra, M., Reifenberger, G., Garvalov, B. K., Acker, T., Acker-Palmer, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974575/
https://www.ncbi.nlm.nih.gov/pubmed/27470974
http://dx.doi.org/10.1038/ncomms12329

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