Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design

If activation of recombinant G protein-coupled receptors in host cells (by drugs or other ligands) has predictive value, similar data must be obtained with native receptors naturally expressed in tissues. Using mouse and human recombinant κ opioid receptors transfected into a host cell, two selectiv...

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Detalles Bibliográficos
Autores principales: Broad, John, Maurel, Damien, Kung, Victor W. S., Hicks, Gareth A., Schemann, Michael, Barnes, Michael R., Kenakin, Terrence P., Granier, Sébastien, Sanger, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974614/
https://www.ncbi.nlm.nih.gov/pubmed/27492592
http://dx.doi.org/10.1038/srep30797

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