Crystal structures of APOBEC3G N-domain alone and its complex with DNA

APOBEC3G (A3G) is a potent restriction factor of HIV-1. The N-terminal domain of A3G (A3G-CD1) is responsible for oligomerization and nucleic acid binding, both of which are essential for anti-HIV activity. As a countermeasure, HIV-1 viral infectivity factor (Vif) binds A3G-CD1 to mediate A3G degrad...

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Detalles Bibliográficos
Autores principales: Xiao, Xiao, Li, Shu-Xing, Yang, Hanjing, Chen, Xiaojiang S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974639/
https://www.ncbi.nlm.nih.gov/pubmed/27480941
http://dx.doi.org/10.1038/ncomms12193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974639/
https://www.ncbi.nlm.nih.gov/pubmed/27480941
http://dx.doi.org/10.1038/ncomms12193

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