Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-in...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Maoyi, Gonzalez-Martin, Alicia, Cooper, Anthony B., Oda, Hiroyo, Jin, Hyun Yong, Shepherd, Jovan, He, Linling, Zhu, Jiang, Nemazee, David, Xiao, Changchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974641/
https://www.ncbi.nlm.nih.gov/pubmed/27481093
http://dx.doi.org/10.1038/ncomms12207
_version_ 1782446580249395200
author Lai, Maoyi
Gonzalez-Martin, Alicia
Cooper, Anthony B.
Oda, Hiroyo
Jin, Hyun Yong
Shepherd, Jovan
He, Linling
Zhu, Jiang
Nemazee, David
Xiao, Changchun
author_facet Lai, Maoyi
Gonzalez-Martin, Alicia
Cooper, Anthony B.
Oda, Hiroyo
Jin, Hyun Yong
Shepherd, Jovan
He, Linling
Zhu, Jiang
Nemazee, David
Xiao, Changchun
author_sort Lai, Maoyi
collection PubMed
description The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways.
format Online
Article
Text
id pubmed-4974641
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-49746412016-08-18 Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs Lai, Maoyi Gonzalez-Martin, Alicia Cooper, Anthony B. Oda, Hiroyo Jin, Hyun Yong Shepherd, Jovan He, Linling Zhu, Jiang Nemazee, David Xiao, Changchun Nat Commun Article The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways. Nature Publishing Group 2016-08-02 /pmc/articles/PMC4974641/ /pubmed/27481093 http://dx.doi.org/10.1038/ncomms12207 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lai, Maoyi
Gonzalez-Martin, Alicia
Cooper, Anthony B.
Oda, Hiroyo
Jin, Hyun Yong
Shepherd, Jovan
He, Linling
Zhu, Jiang
Nemazee, David
Xiao, Changchun
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_full Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_fullStr Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_full_unstemmed Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_short Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_sort regulation of b-cell development and tolerance by different members of the mir-17∼92 family micrornas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974641/
https://www.ncbi.nlm.nih.gov/pubmed/27481093
http://dx.doi.org/10.1038/ncomms12207
work_keys_str_mv AT laimaoyi regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT gonzalezmartinalicia regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT cooperanthonyb regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT odahiroyo regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT jinhyunyong regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT shepherdjovan regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT helinling regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT zhujiang regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT nemazeedavid regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
AT xiaochangchun regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas

Ejemplares similares