Optimal Synthetic Glycosylation of a Therapeutic Antibody

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Glycosylation patterns in antibodies critically determine biological and physical properties but their precise control is a significant challenge in biology and biotechnology. We describe herein the optimization of an endoglycosidase‐catalyzed glycosylation of the best‐selling biotherapeutic Hercept...

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Detalles Bibliográficos
Autores principales: Parsons, Thomas B., Struwe, Weston B., Gault, Joseph, Yamamoto, Keisuke, Taylor, Thomas A., Raj, Ritu, Wals, Kim, Mohammed, Shabaz, Robinson, Carol V., Benesch, Justin L. P., Davis, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Zuschriften
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974915/
https://www.ncbi.nlm.nih.gov/pubmed/27546920
http://dx.doi.org/10.1002/ange.201508723
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