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Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease

BACKGROUND: Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function. OBJECTIVE: To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a...

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Autores principales: Ferreira de Oliveira, Fabricio, Berretta, Juliana Marília, Suchi Chen, Elizabeth, Cardoso Smith, Marilia, Ferreira Bertolucci, Paulo Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Universidad del Valle 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975126/
https://www.ncbi.nlm.nih.gov/pubmed/27546928
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author Ferreira de Oliveira, Fabricio
Berretta, Juliana Marília
Suchi Chen, Elizabeth
Cardoso Smith, Marilia
Ferreira Bertolucci, Paulo Henrique
author_facet Ferreira de Oliveira, Fabricio
Berretta, Juliana Marília
Suchi Chen, Elizabeth
Cardoso Smith, Marilia
Ferreira Bertolucci, Paulo Henrique
author_sort Ferreira de Oliveira, Fabricio
collection PubMed
description BACKGROUND: Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function. OBJECTIVE: To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a pharmacogenetic analysis of the anti-hypertensive effects of angiotensin-converting enzyme inhibitors (ACEis). METHODS: Consecutive outpatients older than 60 years-old with AD and no history of kidney transplant or dialytic therapy were recruited for prospective correlations regarding variations in fasting blood levels of urea and creatinine in one year, considering ACE genotypes of rs1800764 and rs4291 and their respective haplotypes, and treatment with ACEis along with blood pressure variations. RESULTS: For 190 patients, 152 had arterial hypertension, and 122 used ACEis. Minor allele frequencies were 0.492 for rs1800764-C and 0.337 for rs4291-T, both in Hardy-Weinberg equilibrium. There were no overall significant yearly variations in levels of urea and creatinine, but their concurrent variations were positively correlated (ρ <0.0001). Each A allele of rs4291 led to an yearly urea increase of 3,074 mg/dL, and an yearly creatinine increase of 0.044 mg/dL, while the use of ACEis was protective regarding creatinine variations. The use of ACEis was also protective for carriers of rs1800764-CT/rs4291-AA, while carriers of rs1800764-CT/rs4291-AT had steeper reductions in creatinine levels, particularly when they were treated with ACEis. CONCLUSIONS: Effects of ACEis over creatinine variations are genetically mediated and independent of blood pressure variations in older people with AD.
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spelling pubmed-49751262016-08-19 Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease Ferreira de Oliveira, Fabricio Berretta, Juliana Marília Suchi Chen, Elizabeth Cardoso Smith, Marilia Ferreira Bertolucci, Paulo Henrique Colomb Med (Cali) Original Article BACKGROUND: Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function. OBJECTIVE: To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a pharmacogenetic analysis of the anti-hypertensive effects of angiotensin-converting enzyme inhibitors (ACEis). METHODS: Consecutive outpatients older than 60 years-old with AD and no history of kidney transplant or dialytic therapy were recruited for prospective correlations regarding variations in fasting blood levels of urea and creatinine in one year, considering ACE genotypes of rs1800764 and rs4291 and their respective haplotypes, and treatment with ACEis along with blood pressure variations. RESULTS: For 190 patients, 152 had arterial hypertension, and 122 used ACEis. Minor allele frequencies were 0.492 for rs1800764-C and 0.337 for rs4291-T, both in Hardy-Weinberg equilibrium. There were no overall significant yearly variations in levels of urea and creatinine, but their concurrent variations were positively correlated (ρ <0.0001). Each A allele of rs4291 led to an yearly urea increase of 3,074 mg/dL, and an yearly creatinine increase of 0.044 mg/dL, while the use of ACEis was protective regarding creatinine variations. The use of ACEis was also protective for carriers of rs1800764-CT/rs4291-AA, while carriers of rs1800764-CT/rs4291-AT had steeper reductions in creatinine levels, particularly when they were treated with ACEis. CONCLUSIONS: Effects of ACEis over creatinine variations are genetically mediated and independent of blood pressure variations in older people with AD. Universidad del Valle 2016-06-30 /pmc/articles/PMC4975126/ /pubmed/27546928 Text en http://creativecommons.org/licenses/by/3.0/ © 2016. Universidad del Valle. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Original Article
Ferreira de Oliveira, Fabricio
Berretta, Juliana Marília
Suchi Chen, Elizabeth
Cardoso Smith, Marilia
Ferreira Bertolucci, Paulo Henrique
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
title Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
title_full Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
title_fullStr Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
title_full_unstemmed Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
title_short Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
title_sort pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to alzheimer disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975126/
https://www.ncbi.nlm.nih.gov/pubmed/27546928
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