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Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease

Background. CD8(+) T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8(+) T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods. The whole Tc subsets, includi...

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Autores principales: Chen, Long, Chen, Gang, Zhang, Ming-Qiang, Xiong, Xian-Zhi, Liu, Hong-Ju, Xin, Jian-Bao, Zhang, Jian-Chu, Wu, Jiang-Hua, Meng, Zhao-Ji, Sun, Sheng-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975138/
https://www.ncbi.nlm.nih.gov/pubmed/27547589
http://dx.doi.org/10.7717/peerj.2301
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author Chen, Long
Chen, Gang
Zhang, Ming-Qiang
Xiong, Xian-Zhi
Liu, Hong-Ju
Xin, Jian-Bao
Zhang, Jian-Chu
Wu, Jiang-Hua
Meng, Zhao-Ji
Sun, Sheng-Wen
author_facet Chen, Long
Chen, Gang
Zhang, Ming-Qiang
Xiong, Xian-Zhi
Liu, Hong-Ju
Xin, Jian-Bao
Zhang, Jian-Chu
Wu, Jiang-Hua
Meng, Zhao-Ji
Sun, Sheng-Wen
author_sort Chen, Long
collection PubMed
description Background. CD8(+) T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8(+) T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods. The whole Tc subsets, including Tc1/2/10/17, CD8(+) regulatory T cells (Tregs) and CD8(+)α7(+) T cells, were quantified by flow cytometry in peripheral blood from 24 stable COPD subjects (SCOPD), 14 patients during acute exacerbations (AECOPD), and 14 healthy nonsmokers (HN). Results. Acute exacerbations of COPD were accompanied by elevated levels of circulating CD8(+) T cells. Tc1 cells were increased in both SCOPD and AECOPD patients, whereas the percentage of Tc2 cells was decreased in SCOPD patients but remained normal in AECOPD patients. Tc17 cells were increased only in AECOPD patients, and the percentage of Tc10 cells was reduced in both SCOPD and AECOPD patients. The imbalances of pro/anti-inflammatory Tc subsets observed in COPD may be caused by the lack of Tc10 cells and the impaired anti-inflammatory capacity of CD8(+) Tregs. Conclusions. The imbalances between subsets of CD8(+) peripheral blood T cells contribute to the immune response dysfunction in COPD pathogenesis.
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spelling pubmed-49751382016-08-19 Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease Chen, Long Chen, Gang Zhang, Ming-Qiang Xiong, Xian-Zhi Liu, Hong-Ju Xin, Jian-Bao Zhang, Jian-Chu Wu, Jiang-Hua Meng, Zhao-Ji Sun, Sheng-Wen PeerJ Allergy and Clinical Immunology Background. CD8(+) T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8(+) T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods. The whole Tc subsets, including Tc1/2/10/17, CD8(+) regulatory T cells (Tregs) and CD8(+)α7(+) T cells, were quantified by flow cytometry in peripheral blood from 24 stable COPD subjects (SCOPD), 14 patients during acute exacerbations (AECOPD), and 14 healthy nonsmokers (HN). Results. Acute exacerbations of COPD were accompanied by elevated levels of circulating CD8(+) T cells. Tc1 cells were increased in both SCOPD and AECOPD patients, whereas the percentage of Tc2 cells was decreased in SCOPD patients but remained normal in AECOPD patients. Tc17 cells were increased only in AECOPD patients, and the percentage of Tc10 cells was reduced in both SCOPD and AECOPD patients. The imbalances of pro/anti-inflammatory Tc subsets observed in COPD may be caused by the lack of Tc10 cells and the impaired anti-inflammatory capacity of CD8(+) Tregs. Conclusions. The imbalances between subsets of CD8(+) peripheral blood T cells contribute to the immune response dysfunction in COPD pathogenesis. PeerJ Inc. 2016-08-02 /pmc/articles/PMC4975138/ /pubmed/27547589 http://dx.doi.org/10.7717/peerj.2301 Text en ©2016 Chen et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Allergy and Clinical Immunology
Chen, Long
Chen, Gang
Zhang, Ming-Qiang
Xiong, Xian-Zhi
Liu, Hong-Ju
Xin, Jian-Bao
Zhang, Jian-Chu
Wu, Jiang-Hua
Meng, Zhao-Ji
Sun, Sheng-Wen
Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease
title Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease
title_full Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease
title_fullStr Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease
title_full_unstemmed Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease
title_short Imbalance between subsets of CD8(+) peripheral blood T cells in patients with chronic obstructive pulmonary disease
title_sort imbalance between subsets of cd8(+) peripheral blood t cells in patients with chronic obstructive pulmonary disease
topic Allergy and Clinical Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975138/
https://www.ncbi.nlm.nih.gov/pubmed/27547589
http://dx.doi.org/10.7717/peerj.2301
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