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Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study
PURPOSE: The purpose of this study was to examine the efficacy and safety of valproic acid (VPA) use in patients with retinitis pigmentosa (RP). PATIENTS AND METHODS: This was a prospective, interventional, noncomparative case study. In total, 29 eyes from 29 patients with RP whose best-corrected vi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975153/ https://www.ncbi.nlm.nih.gov/pubmed/27536054 http://dx.doi.org/10.2147/OPTH.S109995 |
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author | Iraha, Satoshi Hirami, Yasuhiko Ota, Sachiko Sunagawa, Genshiro A Mandai, Michiko Tanihara, Hidenobu Takahashi, Masayo Kurimoto, Yasuo |
author_facet | Iraha, Satoshi Hirami, Yasuhiko Ota, Sachiko Sunagawa, Genshiro A Mandai, Michiko Tanihara, Hidenobu Takahashi, Masayo Kurimoto, Yasuo |
author_sort | Iraha, Satoshi |
collection | PubMed |
description | PURPOSE: The purpose of this study was to examine the efficacy and safety of valproic acid (VPA) use in patients with retinitis pigmentosa (RP). PATIENTS AND METHODS: This was a prospective, interventional, noncomparative case study. In total, 29 eyes from 29 patients with RP whose best-corrected visual acuities (BCVAs) in logarithm of the minimum angle of resolution (logMAR) ranged from 1.0 to 0.16 with visual fields (VFs) of ≤10° (measured using Goldmann perimeter with I4) were recruited. The patients received oral supplementation with 400 mg of VPA daily for 6 months and were followed for an additional 6 months. BCVAs, VFs (measured with the Humphrey field analyzer central 10-2 program), and subjective questionnaires were examined before, during, and after the cessation of VPA supplementation. RESULTS: The changes in BCVA and VF showed statistically significant differences during the internal use of VPA, compared with after cessation (P=0.001). With VPA intake, BCVA in logMAR significantly improved from baseline to 6 months (P=0.006). The mean deviation value of the VF significantly improved from baseline to 1 month (P=0.001), 3 months (P=0.004), and 6 months (P=0.004). These efficacies, however, were reversed to the baseline levels after the cessation of VPA intake. There were no significant relations between the mean blood VPA concentrations of each patient and the changes in BCVA and VF. During the internal use of VPA, 15 of 29 patients answered “easier to see”, whereas blurred vision was registered in 21 of 29 patients on cessation. No systemic drug-related adverse events were observed. CONCLUSION: While in use, oral intake of VPA indicated a short-term benefit to patients with RP. It is necessary to examine the effect of a longer VPA supplementation in a controlled study design. |
format | Online Article Text |
id | pubmed-4975153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49751532016-08-17 Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study Iraha, Satoshi Hirami, Yasuhiko Ota, Sachiko Sunagawa, Genshiro A Mandai, Michiko Tanihara, Hidenobu Takahashi, Masayo Kurimoto, Yasuo Clin Ophthalmol Clinical Trial Report PURPOSE: The purpose of this study was to examine the efficacy and safety of valproic acid (VPA) use in patients with retinitis pigmentosa (RP). PATIENTS AND METHODS: This was a prospective, interventional, noncomparative case study. In total, 29 eyes from 29 patients with RP whose best-corrected visual acuities (BCVAs) in logarithm of the minimum angle of resolution (logMAR) ranged from 1.0 to 0.16 with visual fields (VFs) of ≤10° (measured using Goldmann perimeter with I4) were recruited. The patients received oral supplementation with 400 mg of VPA daily for 6 months and were followed for an additional 6 months. BCVAs, VFs (measured with the Humphrey field analyzer central 10-2 program), and subjective questionnaires were examined before, during, and after the cessation of VPA supplementation. RESULTS: The changes in BCVA and VF showed statistically significant differences during the internal use of VPA, compared with after cessation (P=0.001). With VPA intake, BCVA in logMAR significantly improved from baseline to 6 months (P=0.006). The mean deviation value of the VF significantly improved from baseline to 1 month (P=0.001), 3 months (P=0.004), and 6 months (P=0.004). These efficacies, however, were reversed to the baseline levels after the cessation of VPA intake. There were no significant relations between the mean blood VPA concentrations of each patient and the changes in BCVA and VF. During the internal use of VPA, 15 of 29 patients answered “easier to see”, whereas blurred vision was registered in 21 of 29 patients on cessation. No systemic drug-related adverse events were observed. CONCLUSION: While in use, oral intake of VPA indicated a short-term benefit to patients with RP. It is necessary to examine the effect of a longer VPA supplementation in a controlled study design. Dove Medical Press 2016-07-25 /pmc/articles/PMC4975153/ /pubmed/27536054 http://dx.doi.org/10.2147/OPTH.S109995 Text en © 2016 Iraha et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Clinical Trial Report Iraha, Satoshi Hirami, Yasuhiko Ota, Sachiko Sunagawa, Genshiro A Mandai, Michiko Tanihara, Hidenobu Takahashi, Masayo Kurimoto, Yasuo Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study |
title | Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study |
title_full | Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study |
title_fullStr | Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study |
title_full_unstemmed | Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study |
title_short | Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study |
title_sort | efficacy of valproic acid for retinitis pigmentosa patients: a pilot study |
topic | Clinical Trial Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975153/ https://www.ncbi.nlm.nih.gov/pubmed/27536054 http://dx.doi.org/10.2147/OPTH.S109995 |
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