Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?

Pentraxin 3 (also known as TNFAIP5, TSG-14) belongs to the superfamily of proteins characterized by cyclic multimeric structure. Pentraxin 3 (PTX3) is synthesized locally at the inflammatory sites by endothelial and smooth muscle cells upon exposure to inflammatory signals such as IL-1β, TNF-α or ox...

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Autores principales: Malinowski, Bartosz, Grzesk, Grzegorz, Grzesk, Elzbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975313/
https://www.ncbi.nlm.nih.gov/pubmed/27683398
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author Malinowski, Bartosz
Grzesk, Grzegorz
Grzesk, Elzbieta
author_facet Malinowski, Bartosz
Grzesk, Grzegorz
Grzesk, Elzbieta
author_sort Malinowski, Bartosz
collection PubMed
description Pentraxin 3 (also known as TNFAIP5, TSG-14) belongs to the superfamily of proteins characterized by cyclic multimeric structure. Pentraxin 3 (PTX3) is synthesized locally at the inflammatory sites by endothelial and smooth muscle cells upon exposure to inflammatory signals such as IL-1β, TNF-α or ox-LDL, but not IL-6. Furthermore, PTX3 is highly expressed in vascular cells and myocardial cells in patients with cardiomyopathy. These data suggest that pentraxin 3 may be a useful biomarker for local vascular inflammation and cardiovascular system disorders.
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spelling pubmed-49753132016-09-28 Pentraxin 3 as a Novel Marker in Cardiovascular Diseases? Malinowski, Bartosz Grzesk, Grzegorz Grzesk, Elzbieta EJIFCC Research Article Pentraxin 3 (also known as TNFAIP5, TSG-14) belongs to the superfamily of proteins characterized by cyclic multimeric structure. Pentraxin 3 (PTX3) is synthesized locally at the inflammatory sites by endothelial and smooth muscle cells upon exposure to inflammatory signals such as IL-1β, TNF-α or ox-LDL, but not IL-6. Furthermore, PTX3 is highly expressed in vascular cells and myocardial cells in patients with cardiomyopathy. These data suggest that pentraxin 3 may be a useful biomarker for local vascular inflammation and cardiovascular system disorders. The Communications and Publications Division (CPD) of the IFCC 2011-12-22 /pmc/articles/PMC4975313/ /pubmed/27683398 Text en Copyright © International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Malinowski, Bartosz
Grzesk, Grzegorz
Grzesk, Elzbieta
Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?
title Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?
title_full Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?
title_fullStr Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?
title_full_unstemmed Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?
title_short Pentraxin 3 as a Novel Marker in Cardiovascular Diseases?
title_sort pentraxin 3 as a novel marker in cardiovascular diseases?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975313/
https://www.ncbi.nlm.nih.gov/pubmed/27683398
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