Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke

The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and...

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Detalles Bibliográficos
Autores principales: Stankovic, Sanja, Stankovic, Aleksandra, Asanin, Milika, Jovanovic-Markovic, Zagorka, Alavantic, Dragan, Majkic-Singh, Nada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975320/
https://www.ncbi.nlm.nih.gov/pubmed/27683381
Descripción
Sumario:The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and control group (p>0.05). Patients with D allele had 4,7 times higher risk for large vessel IS than healthy persons D allele possessors. Persons with D allele had 9.2 times higher risk for large vessel disease than small vessel disease. These data suggest a possible association of ACE gene polymorphism with pathogenesis of large vessel IS.

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