Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke

The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and...

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Autores principales: Stankovic, Sanja, Stankovic, Aleksandra, Asanin, Milika, Jovanovic-Markovic, Zagorka, Alavantic, Dragan, Majkic-Singh, Nada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975320/
https://www.ncbi.nlm.nih.gov/pubmed/27683381
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author Stankovic, Sanja
Stankovic, Aleksandra
Asanin, Milika
Jovanovic-Markovic, Zagorka
Alavantic, Dragan
Majkic-Singh, Nada
author_facet Stankovic, Sanja
Stankovic, Aleksandra
Asanin, Milika
Jovanovic-Markovic, Zagorka
Alavantic, Dragan
Majkic-Singh, Nada
author_sort Stankovic, Sanja
collection PubMed
description The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and control group (p>0.05). Patients with D allele had 4,7 times higher risk for large vessel IS than healthy persons D allele possessors. Persons with D allele had 9.2 times higher risk for large vessel disease than small vessel disease. These data suggest a possible association of ACE gene polymorphism with pathogenesis of large vessel IS.
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spelling pubmed-49753202016-09-28 Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke Stankovic, Sanja Stankovic, Aleksandra Asanin, Milika Jovanovic-Markovic, Zagorka Alavantic, Dragan Majkic-Singh, Nada EJIFCC Research Article The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and control group (p>0.05). Patients with D allele had 4,7 times higher risk for large vessel IS than healthy persons D allele possessors. Persons with D allele had 9.2 times higher risk for large vessel disease than small vessel disease. These data suggest a possible association of ACE gene polymorphism with pathogenesis of large vessel IS. The Communications and Publications Division (CPD) of the IFCC 2011-01-03 /pmc/articles/PMC4975320/ /pubmed/27683381 Text en Copyright © 2010 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Stankovic, Sanja
Stankovic, Aleksandra
Asanin, Milika
Jovanovic-Markovic, Zagorka
Alavantic, Dragan
Majkic-Singh, Nada
Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_full Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_fullStr Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_full_unstemmed Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_short Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_sort angiotensin i - converting enzyme gene polymorphism and activity in patients with ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975320/
https://www.ncbi.nlm.nih.gov/pubmed/27683381
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