The Role of IL-33 in the Inflammation Process of Asthma and Atherosclerosis

Interleukin-33 (IL-33) is a newly found cytokine of the interleukin-1 (IL-1) family. It’s mainly expressed by epithelial and endothelial cells. This expression is upregulated by pro-inflammatory stimulation, thus has an important role in inflammatory responses, such as hypersensitive diseases (asthm...

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Detalles Bibliográficos
Autores principales: Fulgheri, Gabriele, Malinowski, Bartosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975324/
https://www.ncbi.nlm.nih.gov/pubmed/27683395
Descripción
Sumario:Interleukin-33 (IL-33) is a newly found cytokine of the interleukin-1 (IL-1) family. It’s mainly expressed by epithelial and endothelial cells. This expression is upregulated by pro-inflammatory stimulation, thus has an important role in inflammatory responses, such as hypersensitive diseases (asthma), autoimmune diseases (rheumatoid arthritis), cardiovascular diseases (heart failure) and neurodegenerative diseases (Alzheimer). Several studies explored the complicated mechanism of IL-33 action in asthma and atherosclerosis, as this IL is significantly increased in these pathologies, and suggested its potential use in the therapeutic procedures.

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