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Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer
INTRODUCTION: There is a critical need to develop clinical laboratory assays that provide risk assessment for men at elevated risk for prostate cancer, and once diagnosed, could further identify those men with clinically significant disease. METHODS: Recent advancements in analytical instrumentation...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Communications and Publications Division (CPD) of the IFCC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975355/ https://www.ncbi.nlm.nih.gov/pubmed/27683485 |
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author | McDunn, Jonathan E. Stirdivant, Steven M. Ford, Lisa A. Wolfert, Robert L. |
author_facet | McDunn, Jonathan E. Stirdivant, Steven M. Ford, Lisa A. Wolfert, Robert L. |
author_sort | McDunn, Jonathan E. |
collection | PubMed |
description | INTRODUCTION: There is a critical need to develop clinical laboratory assays that provide risk assessment for men at elevated risk for prostate cancer, and once diagnosed, could further identify those men with clinically significant disease. METHODS: Recent advancements in analytical instrumentation have enabled mass spectrometry-based metabolomics methodologies. Further advancements in chromatographic techniques have facilitated high throughput, quantitative assays for a broad spectrum of biochemicals. RESULTS: Screening metabolomics techniques have been applied to biospecimens from large cohorts of men comparing those individuals with prostate cancer to those with no evidence of malignancy. Work beginning in tissues has identified biochemical profiles that correlate with disease and disease severity, including tumor grade and stage. Some of these metabolic abnormalities, such as dramatic elevations in sarcosine, have been found to translate into biological fluids, especially blood and urine, which can be sampled in a minimally invasive manner. DISCUSSION: The differential abundances of these tumor-associated metabolites have been found to improve the performance of clinical prognostic/diagnostic tools. CONCLUSION: The outlook is bright for metabolomic technology to address clinical diagnostic needs for prostate cancer patient management. Early validation of specific clinical tests provides a preview of further successes in this area. Metabolomics has shown its utility to complement and augment traditional clinical approaches as well as emerging genomic, transcriptomic and proteomic methodologies, and is expected to play a key role in the precision medicine-based management of the prostate cancer patient. |
format | Online Article Text |
id | pubmed-4975355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Communications and Publications Division (CPD) of the IFCC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49753552016-09-28 Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer McDunn, Jonathan E. Stirdivant, Steven M. Ford, Lisa A. Wolfert, Robert L. EJIFCC Research Article INTRODUCTION: There is a critical need to develop clinical laboratory assays that provide risk assessment for men at elevated risk for prostate cancer, and once diagnosed, could further identify those men with clinically significant disease. METHODS: Recent advancements in analytical instrumentation have enabled mass spectrometry-based metabolomics methodologies. Further advancements in chromatographic techniques have facilitated high throughput, quantitative assays for a broad spectrum of biochemicals. RESULTS: Screening metabolomics techniques have been applied to biospecimens from large cohorts of men comparing those individuals with prostate cancer to those with no evidence of malignancy. Work beginning in tissues has identified biochemical profiles that correlate with disease and disease severity, including tumor grade and stage. Some of these metabolic abnormalities, such as dramatic elevations in sarcosine, have been found to translate into biological fluids, especially blood and urine, which can be sampled in a minimally invasive manner. DISCUSSION: The differential abundances of these tumor-associated metabolites have been found to improve the performance of clinical prognostic/diagnostic tools. CONCLUSION: The outlook is bright for metabolomic technology to address clinical diagnostic needs for prostate cancer patient management. Early validation of specific clinical tests provides a preview of further successes in this area. Metabolomics has shown its utility to complement and augment traditional clinical approaches as well as emerging genomic, transcriptomic and proteomic methodologies, and is expected to play a key role in the precision medicine-based management of the prostate cancer patient. The Communications and Publications Division (CPD) of the IFCC 2015-03-10 /pmc/articles/PMC4975355/ /pubmed/27683485 Text en Copyright © 2015 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article McDunn, Jonathan E. Stirdivant, Steven M. Ford, Lisa A. Wolfert, Robert L. Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer |
title | Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer |
title_full | Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer |
title_fullStr | Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer |
title_full_unstemmed | Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer |
title_short | Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer |
title_sort | metabolomics and its application to the development of clinical laboratory tests for prostate cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975355/ https://www.ncbi.nlm.nih.gov/pubmed/27683485 |
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