Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-Antibodies

Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and phosphatidylserine (PS) externalization in a cohort of adul...

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Detalles Bibliográficos
Autores principales: Goette, Nora P., Glembotsky, Ana C., Lev, Paola R., Grodzielski, Matías, Contrufo, Geraldine, Pierdominici, Marta S., Espasandin, Yesica R., Riveros, Dardo, García, Alejandro J., Molinas, Felisa C., Heller, Paula G., Marta, Rosana F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975454/
https://www.ncbi.nlm.nih.gov/pubmed/27494140
http://dx.doi.org/10.1371/journal.pone.0160563

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