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DNA Methylation Suppresses Leptin Gene in 3T3-L1 Adipocytes

Leptin is a key regulator of energy intake and expenditure. This peptide hormone is expressed in mouse white adipose tissue, but hardly expressed in 3T3-L1 adipocytes. Using bisulfite sequencing, we found that CpG islands in the leptin promoter are highly methylated in 3T3-L1cells. 5-azacytidine, an...

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Detalles Bibliográficos
Autores principales:	Kuroda, Masashi, Tominaga, Ayako, Nakagawa, Kasumi, Nishiguchi, Misa, Sebe, Mayu, Miyatake, Yumiko, Kitamura, Tadahiro, Tsutsumi, Rie, Harada, Nagakatsu, Nakaya, Yutaka, Sakaue, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975473/ https://www.ncbi.nlm.nih.gov/pubmed/27494408 http://dx.doi.org/10.1371/journal.pone.0160532

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