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Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length
To estimate the effect of tobacco smoking on iron homeostasis and the possible association between hepcidin and the neonatal birth weight and length, concentrations of serum hepcidin and selected iron markers were measured in 81 healthy pregnant women (41 smokers and 40 nonsmokers). The smoking moth...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975765/ https://www.ncbi.nlm.nih.gov/pubmed/26785641 http://dx.doi.org/10.1007/s12011-016-0621-7 |
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author | Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Jabłońska-Głąb, Ewa Maciejewski, Tomasz M. Ołtarzewski, Mariusz |
author_facet | Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Jabłońska-Głąb, Ewa Maciejewski, Tomasz M. Ołtarzewski, Mariusz |
author_sort | Chełchowska, Magdalena |
collection | PubMed |
description | To estimate the effect of tobacco smoking on iron homeostasis and the possible association between hepcidin and the neonatal birth weight and length, concentrations of serum hepcidin and selected iron markers were measured in 81 healthy pregnant women (41 smokers and 40 nonsmokers). The smoking mothers had significantly lower concentrations of serum hepcidin (p < 0.001), iron (p < 0.001), and hemoglobin (p < 0.05), but higher erythropoietin (p < 0.05) levels compared with non-smoking pregnant women. Logistic regression analysis showed the highest negative impact of the number of cigarettes smoked per day (β = −0.46; p < 0.01) and positive impact of ferritin level (β = 0.47; p < 0.001) on serum hepcidin concentration. The birth weight and the body length of smoking mothers’ infants were significantly lower than in tobacco abstinent group (p < 0.001). In multiple regression analysis, birth body weight (β = 0.56; p < 0.001) and length (β = 0.50; p < 0.001) were significantly related to maternal hepcidin values. Tobacco smoking affected hepcidin level in serum of pregnant women in a dose-dependent manner. Low concentrations of iron and hemoglobin in maternal serum coexisting with high level of erythropoietin suggest that smoking could lead to subclinical iron deficiency and chronic hypoxia not only in mothers but also in fetus. Low serum hepcidin concentration in smoking pregnant women might be associated with lower fetal birth weight and length. |
format | Online Article Text |
id | pubmed-4975765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-49757652016-08-18 Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Jabłońska-Głąb, Ewa Maciejewski, Tomasz M. Ołtarzewski, Mariusz Biol Trace Elem Res Article To estimate the effect of tobacco smoking on iron homeostasis and the possible association between hepcidin and the neonatal birth weight and length, concentrations of serum hepcidin and selected iron markers were measured in 81 healthy pregnant women (41 smokers and 40 nonsmokers). The smoking mothers had significantly lower concentrations of serum hepcidin (p < 0.001), iron (p < 0.001), and hemoglobin (p < 0.05), but higher erythropoietin (p < 0.05) levels compared with non-smoking pregnant women. Logistic regression analysis showed the highest negative impact of the number of cigarettes smoked per day (β = −0.46; p < 0.01) and positive impact of ferritin level (β = 0.47; p < 0.001) on serum hepcidin concentration. The birth weight and the body length of smoking mothers’ infants were significantly lower than in tobacco abstinent group (p < 0.001). In multiple regression analysis, birth body weight (β = 0.56; p < 0.001) and length (β = 0.50; p < 0.001) were significantly related to maternal hepcidin values. Tobacco smoking affected hepcidin level in serum of pregnant women in a dose-dependent manner. Low concentrations of iron and hemoglobin in maternal serum coexisting with high level of erythropoietin suggest that smoking could lead to subclinical iron deficiency and chronic hypoxia not only in mothers but also in fetus. Low serum hepcidin concentration in smoking pregnant women might be associated with lower fetal birth weight and length. Springer US 2016-01-20 2016 /pmc/articles/PMC4975765/ /pubmed/26785641 http://dx.doi.org/10.1007/s12011-016-0621-7 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Jabłońska-Głąb, Ewa Maciejewski, Tomasz M. Ołtarzewski, Mariusz Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length |
title | Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length |
title_full | Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length |
title_fullStr | Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length |
title_full_unstemmed | Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length |
title_short | Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length |
title_sort | hepcidin and iron metabolism in pregnancy: correlation with smoking and birth weight and length |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975765/ https://www.ncbi.nlm.nih.gov/pubmed/26785641 http://dx.doi.org/10.1007/s12011-016-0621-7 |
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