The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression

OBJECTIVES: To identify the functional basis for the genetic association of single nucleotide polymorphisms (SNP), upstream of the RUNX3 promoter, with ankylosing spondylitis (AS). METHODS: We performed conditional analysis of genetic association data and used ENCODE data on chromatin remodelling an...

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Detalles Bibliográficos
Autores principales: Vecellio, Matteo, Roberts, Amity R, Cohen, Carla J, Cortes, Adrian, Knight, Julian C, Bowness, Paul, Wordsworth, B Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975853/
https://www.ncbi.nlm.nih.gov/pubmed/26452539
http://dx.doi.org/10.1136/annrheumdis-2015-207490

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