A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin

Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, although recent studies have started to emerge in CRS patient refractory to maximal medical...

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Autores principales: Lefrançois, Philippe, Chapdelaine, Hugo, Côté, Benoît, Desrosiers, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975886/
https://www.ncbi.nlm.nih.gov/pubmed/27499767
http://dx.doi.org/10.1186/s13223-016-0141-1
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author Lefrançois, Philippe
Chapdelaine, Hugo
Côté, Benoît
Desrosiers, Martin
author_facet Lefrançois, Philippe
Chapdelaine, Hugo
Côté, Benoît
Desrosiers, Martin
author_sort Lefrançois, Philippe
collection PubMed
description Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, although recent studies have started to emerge in CRS patient refractory to maximal medical management. We discuss the possible auto-immunity link between CRS and other skin diseases, in particular acquired bullous dermatoses, and review the current evidence. We raise additional considerations for auto-immunity from both research and clinical standpoints.
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spelling pubmed-49758862016-08-07 A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin Lefrançois, Philippe Chapdelaine, Hugo Côté, Benoît Desrosiers, Martin Allergy Asthma Clin Immunol Review Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, although recent studies have started to emerge in CRS patient refractory to maximal medical management. We discuss the possible auto-immunity link between CRS and other skin diseases, in particular acquired bullous dermatoses, and review the current evidence. We raise additional considerations for auto-immunity from both research and clinical standpoints. BioMed Central 2016-08-05 /pmc/articles/PMC4975886/ /pubmed/27499767 http://dx.doi.org/10.1186/s13223-016-0141-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Lefrançois, Philippe
Chapdelaine, Hugo
Côté, Benoît
Desrosiers, Martin
A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin
title A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin
title_full A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin
title_fullStr A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin
title_full_unstemmed A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin
title_short A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin
title_sort role for auto-immunity in chronic rhinosinusitis? lessons learned from sub-epidermal bullous disorders of the skin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975886/
https://www.ncbi.nlm.nih.gov/pubmed/27499767
http://dx.doi.org/10.1186/s13223-016-0141-1
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