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Epidermal Growth Factor and Intestinal Barrier Function
Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier int...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976184/ https://www.ncbi.nlm.nih.gov/pubmed/27524860 http://dx.doi.org/10.1155/2016/1927348 |
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author | Tang, Xiaopeng Liu, Hu Yang, Shufen Li, Zuohua Zhong, Jinfeng Fang, Rejun |
author_facet | Tang, Xiaopeng Liu, Hu Yang, Shufen Li, Zuohua Zhong, Jinfeng Fang, Rejun |
author_sort | Tang, Xiaopeng |
collection | PubMed |
description | Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier function. In this review, the relationship between epidermal growth factor and intestinal development and intestinal barrier is described, to provide a better understanding of the effects of EGF on intestine development and health. |
format | Online Article Text |
id | pubmed-4976184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49761842016-08-14 Epidermal Growth Factor and Intestinal Barrier Function Tang, Xiaopeng Liu, Hu Yang, Shufen Li, Zuohua Zhong, Jinfeng Fang, Rejun Mediators Inflamm Review Article Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier function. In this review, the relationship between epidermal growth factor and intestinal development and intestinal barrier is described, to provide a better understanding of the effects of EGF on intestine development and health. Hindawi Publishing Corporation 2016 2016-07-25 /pmc/articles/PMC4976184/ /pubmed/27524860 http://dx.doi.org/10.1155/2016/1927348 Text en Copyright © 2016 Xiaopeng Tang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tang, Xiaopeng Liu, Hu Yang, Shufen Li, Zuohua Zhong, Jinfeng Fang, Rejun Epidermal Growth Factor and Intestinal Barrier Function |
title | Epidermal Growth Factor and Intestinal Barrier Function |
title_full | Epidermal Growth Factor and Intestinal Barrier Function |
title_fullStr | Epidermal Growth Factor and Intestinal Barrier Function |
title_full_unstemmed | Epidermal Growth Factor and Intestinal Barrier Function |
title_short | Epidermal Growth Factor and Intestinal Barrier Function |
title_sort | epidermal growth factor and intestinal barrier function |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976184/ https://www.ncbi.nlm.nih.gov/pubmed/27524860 http://dx.doi.org/10.1155/2016/1927348 |
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