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Epidermal Growth Factor and Intestinal Barrier Function

Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier int...

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Detalles Bibliográficos
Autores principales: Tang, Xiaopeng, Liu, Hu, Yang, Shufen, Li, Zuohua, Zhong, Jinfeng, Fang, Rejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976184/
https://www.ncbi.nlm.nih.gov/pubmed/27524860
http://dx.doi.org/10.1155/2016/1927348
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author Tang, Xiaopeng
Liu, Hu
Yang, Shufen
Li, Zuohua
Zhong, Jinfeng
Fang, Rejun
author_facet Tang, Xiaopeng
Liu, Hu
Yang, Shufen
Li, Zuohua
Zhong, Jinfeng
Fang, Rejun
author_sort Tang, Xiaopeng
collection PubMed
description Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier function. In this review, the relationship between epidermal growth factor and intestinal development and intestinal barrier is described, to provide a better understanding of the effects of EGF on intestine development and health.
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spelling pubmed-49761842016-08-14 Epidermal Growth Factor and Intestinal Barrier Function Tang, Xiaopeng Liu, Hu Yang, Shufen Li, Zuohua Zhong, Jinfeng Fang, Rejun Mediators Inflamm Review Article Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier function. In this review, the relationship between epidermal growth factor and intestinal development and intestinal barrier is described, to provide a better understanding of the effects of EGF on intestine development and health. Hindawi Publishing Corporation 2016 2016-07-25 /pmc/articles/PMC4976184/ /pubmed/27524860 http://dx.doi.org/10.1155/2016/1927348 Text en Copyright © 2016 Xiaopeng Tang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tang, Xiaopeng
Liu, Hu
Yang, Shufen
Li, Zuohua
Zhong, Jinfeng
Fang, Rejun
Epidermal Growth Factor and Intestinal Barrier Function
title Epidermal Growth Factor and Intestinal Barrier Function
title_full Epidermal Growth Factor and Intestinal Barrier Function
title_fullStr Epidermal Growth Factor and Intestinal Barrier Function
title_full_unstemmed Epidermal Growth Factor and Intestinal Barrier Function
title_short Epidermal Growth Factor and Intestinal Barrier Function
title_sort epidermal growth factor and intestinal barrier function
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976184/
https://www.ncbi.nlm.nih.gov/pubmed/27524860
http://dx.doi.org/10.1155/2016/1927348
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