AAV9-mediated gene transfer of desmin ameliorates cardiomyopathy in desmin-deficient mice

Mutations of the human desmin (DES) gene cause autosomal dominant and recessive myopathies affecting skeletal and cardiac muscle tissue. Desmin knockout mice (DES-KO), which develop progressive myopathy and cardiomyopathy, mirror rare human recessive desminopathies in which mutations on both DES all...

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Detalles Bibliográficos
Autores principales: Heckmann, M B, Bauer, R, Jungmann, A, Winter, L, Rapti, K, Strucksberg, K-H, Clemen, C S, Li, Z, Schröder, R, Katus, H A, Müller, O J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976287/
https://www.ncbi.nlm.nih.gov/pubmed/27101257
http://dx.doi.org/10.1038/gt.2016.40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976287/
https://www.ncbi.nlm.nih.gov/pubmed/27101257
http://dx.doi.org/10.1038/gt.2016.40

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