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Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing

Interleukin-8 (IL-8) gene polymorphisms have been considered as susceptibility factors in periodontal disease. However, the functional roles of IL-8 gene haplotypes have not been investigated. Here, we demonstrate for the first time the use of the CRISPR/Cas9 system to engineer the IL-8 gene, and te...

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Detalles Bibliográficos
Autores principales:	Benakanakere, Manjunatha R., Finoti, Livia S., Tanaka, Urara, Grant, Gregory R., Scarel-Caminaga, Raquel M., Kinane, Denis F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976357/ https://www.ncbi.nlm.nih.gov/pubmed/27499075 http://dx.doi.org/10.1038/srep31180

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