Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

Dimethyl fumarate (DMF) possesses anti-inflammatory properties and is approved for the treatment of psoriasis and multiple sclerosis. While clinically effective, its molecular target has remained elusive - although it is known to activate anti-oxidant pathways. We find that DMF inhibits pro-inflamma...

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Detalles Bibliográficos
Autores principales: McGuire, Victoria A., Ruiz-Zorrilla Diez, Tamara, Emmerich, Christoph H., Strickson, Sam, Ritorto, Maria Stella, Sutavani, Ruhcha V., Weiβ, Anne, Houslay, Kirsty F., Knebel, Axel, Meakin, Paul J., Phair, Iain R., Ashford, Michael L. J., Trost, Matthias, Arthur, J. Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976367/
https://www.ncbi.nlm.nih.gov/pubmed/27498693
http://dx.doi.org/10.1038/srep31159

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