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Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response

The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX), the active ingredient of the antidepressant drug Prozac, inhibits reuptake of the neurotransmitter, serotonin (5-HT; 5-hydroxytryptamine), into cells by the 5-HT transporter (SERT). Given the role of 5-HT in oxygen detection and the...

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Autores principales: Panlilio, Jennifer M., Marin, Sara, Lobl, Marissa B., McDonald, M. Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976378/
https://www.ncbi.nlm.nih.gov/pubmed/27499056
http://dx.doi.org/10.1038/srep31148
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author Panlilio, Jennifer M.
Marin, Sara
Lobl, Marissa B.
McDonald, M. Danielle
author_facet Panlilio, Jennifer M.
Marin, Sara
Lobl, Marissa B.
McDonald, M. Danielle
author_sort Panlilio, Jennifer M.
collection PubMed
description The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX), the active ingredient of the antidepressant drug Prozac, inhibits reuptake of the neurotransmitter, serotonin (5-HT; 5-hydroxytryptamine), into cells by the 5-HT transporter (SERT). Given the role of 5-HT in oxygen detection and the cardiovascular and ventilatory responses of fish to hypoxia, we hypothesized that treatment of the Gulf toadfish, Opsanus beta, with FLX would interfere with their response to hypoxia. Toadfish treated intra-arterially with 3.4 μg.g(−1) FLX under normoxic conditions displayed a transient tachycardia and a biphasic caudal arterial blood pressure (P(CA)) response that are in direct conflict with the typical hypoxia response. Fish injected intraperitoneally with FLX under normoxia had resting cardiovascular and ventilatory parameters similar to controls. Upon exposure to hypoxia, control toadfish exhibit a significant bradycardia, reduction in P(CA) and an increase in ventilatory amplitude (V(AMP)) without any changes in ventilatory frequency (fV). Fish treated IP with 10 μg.g(−1) FLX showed an interference in the cardiovascular and ventilatory response to hypoxia. Interestingly, when treated with 25 μg.g(−1) FLX, the bradycardia and V(AMP) response to hypoxia were similar to control fish while the P(CA) response to hypoxia was further inhibited. These results suggest that SERT inhibition by FLX may hinder survival in hypoxia.
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spelling pubmed-49763782016-08-22 Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response Panlilio, Jennifer M. Marin, Sara Lobl, Marissa B. McDonald, M. Danielle Sci Rep Article The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX), the active ingredient of the antidepressant drug Prozac, inhibits reuptake of the neurotransmitter, serotonin (5-HT; 5-hydroxytryptamine), into cells by the 5-HT transporter (SERT). Given the role of 5-HT in oxygen detection and the cardiovascular and ventilatory responses of fish to hypoxia, we hypothesized that treatment of the Gulf toadfish, Opsanus beta, with FLX would interfere with their response to hypoxia. Toadfish treated intra-arterially with 3.4 μg.g(−1) FLX under normoxic conditions displayed a transient tachycardia and a biphasic caudal arterial blood pressure (P(CA)) response that are in direct conflict with the typical hypoxia response. Fish injected intraperitoneally with FLX under normoxia had resting cardiovascular and ventilatory parameters similar to controls. Upon exposure to hypoxia, control toadfish exhibit a significant bradycardia, reduction in P(CA) and an increase in ventilatory amplitude (V(AMP)) without any changes in ventilatory frequency (fV). Fish treated IP with 10 μg.g(−1) FLX showed an interference in the cardiovascular and ventilatory response to hypoxia. Interestingly, when treated with 25 μg.g(−1) FLX, the bradycardia and V(AMP) response to hypoxia were similar to control fish while the P(CA) response to hypoxia was further inhibited. These results suggest that SERT inhibition by FLX may hinder survival in hypoxia. Nature Publishing Group 2016-08-08 /pmc/articles/PMC4976378/ /pubmed/27499056 http://dx.doi.org/10.1038/srep31148 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Panlilio, Jennifer M.
Marin, Sara
Lobl, Marissa B.
McDonald, M. Danielle
Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
title Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
title_full Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
title_fullStr Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
title_full_unstemmed Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
title_short Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
title_sort treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976378/
https://www.ncbi.nlm.nih.gov/pubmed/27499056
http://dx.doi.org/10.1038/srep31148
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