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Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation
BACKGROUND: We investigated the pharmacokinetics of etoposide (ETP) to reduce the inter-individual variations of ETP concentrations in patients with acute leukemia who underwent allogeneic hematopoietic stem cell transplantation. We also carried out an in vivo study using rats to verify the dose adj...
Autores principales: | Tazawa, Yuki, Shigematsu, Akio, Kasashi, Kumiko, Sugita, Junichi, Endo, Tomoyuki, Kondo, Takeshi, Teshima, Takanori, Iseki, Ken, Sugawara, Mitsuru, Takekuma, Yoh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976473/ https://www.ncbi.nlm.nih.gov/pubmed/27504190 http://dx.doi.org/10.1186/s40780-016-0052-9 |
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