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A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters

OBJECTIVE: To determine the power-law exponents (D) of emphysema hole-size distributions as a competent emphysema index. Robustness to extreme breath-hold-level variations and correlations with clinical parameters for chronic obstructive pulmonary disease (COPD) were investigated and compared to a c...

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Autores principales: Hwang, Jeongeun, Lee, Minho, Lee, Sang Min, Oh, Sang Young, Oh, Yeon-Mok, Kim, Namkug, Seo, Joon Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976821/
https://www.ncbi.nlm.nih.gov/pubmed/27536095
http://dx.doi.org/10.2147/COPD.S109846
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author Hwang, Jeongeun
Lee, Minho
Lee, Sang Min
Oh, Sang Young
Oh, Yeon-Mok
Kim, Namkug
Seo, Joon Beom
author_facet Hwang, Jeongeun
Lee, Minho
Lee, Sang Min
Oh, Sang Young
Oh, Yeon-Mok
Kim, Namkug
Seo, Joon Beom
author_sort Hwang, Jeongeun
collection PubMed
description OBJECTIVE: To determine the power-law exponents (D) of emphysema hole-size distributions as a competent emphysema index. Robustness to extreme breath-hold-level variations and correlations with clinical parameters for chronic obstructive pulmonary disease (COPD) were investigated and compared to a conventional emphysema index (EI%). PATIENTS AND METHODS: A total of 100 patients with COPD (97 males and three females of mean age 67±7.9 years) underwent multidetector row computed tomography scanning at full inspiration and full expiration. The diameters of the emphysematous holes were estimated and quantified with a fully automated algorithm. Power-law exponents (D) of emphysematous hole-size distribution were evaluated. RESULTS: The diameters followed a power-law distribution in all cases, suggesting the scale-free nature of emphysema. D of inspiratory and expiratory computed tomography of patients showed intraclass correlation coefficients >0.8, indicating statistically absolute agreement of different breath-hold levels. By contrast, the EI% failed to agree. Bland–Altman analysis also revealed the superior robustness of D to EI%. D also significantly correlated with clinical parameters such as airflow limitation, diffusion capacity, exercise capacity, and quality of life. CONCLUSION: The D of emphysematous hole-size distribution is robust to breath-hold-level variations and sensitive to the severity of emphysema. This measurement may help rule out the confounding effects of variations in breath-hold levels.
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spelling pubmed-49768212016-08-17 A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters Hwang, Jeongeun Lee, Minho Lee, Sang Min Oh, Sang Young Oh, Yeon-Mok Kim, Namkug Seo, Joon Beom Int J Chron Obstruct Pulmon Dis Original Research OBJECTIVE: To determine the power-law exponents (D) of emphysema hole-size distributions as a competent emphysema index. Robustness to extreme breath-hold-level variations and correlations with clinical parameters for chronic obstructive pulmonary disease (COPD) were investigated and compared to a conventional emphysema index (EI%). PATIENTS AND METHODS: A total of 100 patients with COPD (97 males and three females of mean age 67±7.9 years) underwent multidetector row computed tomography scanning at full inspiration and full expiration. The diameters of the emphysematous holes were estimated and quantified with a fully automated algorithm. Power-law exponents (D) of emphysematous hole-size distribution were evaluated. RESULTS: The diameters followed a power-law distribution in all cases, suggesting the scale-free nature of emphysema. D of inspiratory and expiratory computed tomography of patients showed intraclass correlation coefficients >0.8, indicating statistically absolute agreement of different breath-hold levels. By contrast, the EI% failed to agree. Bland–Altman analysis also revealed the superior robustness of D to EI%. D also significantly correlated with clinical parameters such as airflow limitation, diffusion capacity, exercise capacity, and quality of life. CONCLUSION: The D of emphysematous hole-size distribution is robust to breath-hold-level variations and sensitive to the severity of emphysema. This measurement may help rule out the confounding effects of variations in breath-hold levels. Dove Medical Press 2016-08-03 /pmc/articles/PMC4976821/ /pubmed/27536095 http://dx.doi.org/10.2147/COPD.S109846 Text en © 2016 Hwang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Hwang, Jeongeun
Lee, Minho
Lee, Sang Min
Oh, Sang Young
Oh, Yeon-Mok
Kim, Namkug
Seo, Joon Beom
A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
title A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
title_full A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
title_fullStr A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
title_full_unstemmed A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
title_short A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
title_sort size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976821/
https://www.ncbi.nlm.nih.gov/pubmed/27536095
http://dx.doi.org/10.2147/COPD.S109846
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