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A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters
OBJECTIVE: To determine the power-law exponents (D) of emphysema hole-size distributions as a competent emphysema index. Robustness to extreme breath-hold-level variations and correlations with clinical parameters for chronic obstructive pulmonary disease (COPD) were investigated and compared to a c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976821/ https://www.ncbi.nlm.nih.gov/pubmed/27536095 http://dx.doi.org/10.2147/COPD.S109846 |
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author | Hwang, Jeongeun Lee, Minho Lee, Sang Min Oh, Sang Young Oh, Yeon-Mok Kim, Namkug Seo, Joon Beom |
author_facet | Hwang, Jeongeun Lee, Minho Lee, Sang Min Oh, Sang Young Oh, Yeon-Mok Kim, Namkug Seo, Joon Beom |
author_sort | Hwang, Jeongeun |
collection | PubMed |
description | OBJECTIVE: To determine the power-law exponents (D) of emphysema hole-size distributions as a competent emphysema index. Robustness to extreme breath-hold-level variations and correlations with clinical parameters for chronic obstructive pulmonary disease (COPD) were investigated and compared to a conventional emphysema index (EI%). PATIENTS AND METHODS: A total of 100 patients with COPD (97 males and three females of mean age 67±7.9 years) underwent multidetector row computed tomography scanning at full inspiration and full expiration. The diameters of the emphysematous holes were estimated and quantified with a fully automated algorithm. Power-law exponents (D) of emphysematous hole-size distribution were evaluated. RESULTS: The diameters followed a power-law distribution in all cases, suggesting the scale-free nature of emphysema. D of inspiratory and expiratory computed tomography of patients showed intraclass correlation coefficients >0.8, indicating statistically absolute agreement of different breath-hold levels. By contrast, the EI% failed to agree. Bland–Altman analysis also revealed the superior robustness of D to EI%. D also significantly correlated with clinical parameters such as airflow limitation, diffusion capacity, exercise capacity, and quality of life. CONCLUSION: The D of emphysematous hole-size distribution is robust to breath-hold-level variations and sensitive to the severity of emphysema. This measurement may help rule out the confounding effects of variations in breath-hold levels. |
format | Online Article Text |
id | pubmed-4976821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49768212016-08-17 A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters Hwang, Jeongeun Lee, Minho Lee, Sang Min Oh, Sang Young Oh, Yeon-Mok Kim, Namkug Seo, Joon Beom Int J Chron Obstruct Pulmon Dis Original Research OBJECTIVE: To determine the power-law exponents (D) of emphysema hole-size distributions as a competent emphysema index. Robustness to extreme breath-hold-level variations and correlations with clinical parameters for chronic obstructive pulmonary disease (COPD) were investigated and compared to a conventional emphysema index (EI%). PATIENTS AND METHODS: A total of 100 patients with COPD (97 males and three females of mean age 67±7.9 years) underwent multidetector row computed tomography scanning at full inspiration and full expiration. The diameters of the emphysematous holes were estimated and quantified with a fully automated algorithm. Power-law exponents (D) of emphysematous hole-size distribution were evaluated. RESULTS: The diameters followed a power-law distribution in all cases, suggesting the scale-free nature of emphysema. D of inspiratory and expiratory computed tomography of patients showed intraclass correlation coefficients >0.8, indicating statistically absolute agreement of different breath-hold levels. By contrast, the EI% failed to agree. Bland–Altman analysis also revealed the superior robustness of D to EI%. D also significantly correlated with clinical parameters such as airflow limitation, diffusion capacity, exercise capacity, and quality of life. CONCLUSION: The D of emphysematous hole-size distribution is robust to breath-hold-level variations and sensitive to the severity of emphysema. This measurement may help rule out the confounding effects of variations in breath-hold levels. Dove Medical Press 2016-08-03 /pmc/articles/PMC4976821/ /pubmed/27536095 http://dx.doi.org/10.2147/COPD.S109846 Text en © 2016 Hwang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Hwang, Jeongeun Lee, Minho Lee, Sang Min Oh, Sang Young Oh, Yeon-Mok Kim, Namkug Seo, Joon Beom A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters |
title | A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters |
title_full | A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters |
title_fullStr | A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters |
title_full_unstemmed | A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters |
title_short | A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters |
title_sort | size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976821/ https://www.ncbi.nlm.nih.gov/pubmed/27536095 http://dx.doi.org/10.2147/COPD.S109846 |
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